Effect of Poloxamer on release of poorly water soluble drug Loratadine from solid dispersion: Kneading method

Effect of Poloxamer on release of poorly water soluble drug Loratadine from solid dispersion: Kneading method

The main objective of the current study was to enhance the solubility and dissolution of poorly water soluble drug Loratadine (LOR) through formulation of solid dispersion systems (SDs) using hydrophilic polymers. SDs were prepared by kneading method using different drug-to-polymer ratios (1:3 and...

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Main Authors: M. Mofizur Rahman, Mohammad Moniruzzaman, Sanjida Haque, M.A.K. Azad, Farjana Islam Aovi, Nazneen Ahmeda Sultana
Format: Article
Language:English
Published: University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association 2015-05-01
Series:Makedonsko Farmacevtski Bilten
Online Access:http://bulletin.mfd.org.mk/volumes/Volume%2061_1/61_1_001.pdf
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spelling doaj-f02ce360380d41829c1ab8347c954eb52020-11-24T20:52:13ZengUniversity Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical AssociationMakedonsko Farmacevtski Bilten1409-86951857-89692015-05-0161(1)4550Effect of Poloxamer on release of poorly water soluble drug Loratadine from solid dispersion: Kneading methodM. Mofizur Rahman0Mohammad Moniruzzaman1Sanjida Haque2M.A.K. Azad3Farjana Islam Aovi4Nazneen Ahmeda Sultana5Department of Pharmacy, Bangladesh University, Dhaka, Bangladesh Department of Pharmacy, Bangladesh University, Dhaka, Bangladesh Department of Pharmacy, Bangladesh University, Dhaka, Bangladesh Department of Pharmacy, Bangladesh University, Dhaka, Bangladesh Pharmacy Discipline, Khulna University, Khulna, BangladeshDepartment of Pharmacy, Bangladesh University, Dhaka, Bangladesh The main objective of the current study was to enhance the solubility and dissolution of poorly water soluble drug Loratadine (LOR) through formulation of solid dispersion systems (SDs) using hydrophilic polymers. SDs were prepared by kneading method using different drug-to-polymer ratios (1:3 and 1:5) with poloxomer 188 (samples DS1, DS2) and poloxomer 407 (samples DS3, DS4) as hydrophilic polymers. In vitro drug release studies were performed on prepared SDs (DS1-DS4) and compared to pure drug (LOR only, sample DS0). Prepared SDs showed significant improvement in the release profile compared to LOR.http://bulletin.mfd.org.mk/volumes/Volume%2061_1/61_1_001.pdf
collection DOAJ
language English
format Article
sources DOAJ
author M. Mofizur Rahman
Mohammad Moniruzzaman
Sanjida Haque
M.A.K. Azad
Farjana Islam Aovi
Nazneen Ahmeda Sultana
spellingShingle M. Mofizur Rahman
Mohammad Moniruzzaman
Sanjida Haque
M.A.K. Azad
Farjana Islam Aovi
Nazneen Ahmeda Sultana
Effect of Poloxamer on release of poorly water soluble drug Loratadine from solid dispersion: Kneading method
Makedonsko Farmacevtski Bilten
author_facet M. Mofizur Rahman
Mohammad Moniruzzaman
Sanjida Haque
M.A.K. Azad
Farjana Islam Aovi
Nazneen Ahmeda Sultana
author_sort M. Mofizur Rahman
title Effect of Poloxamer on release of poorly water soluble drug Loratadine from solid dispersion: Kneading method
title_short Effect of Poloxamer on release of poorly water soluble drug Loratadine from solid dispersion: Kneading method
title_full Effect of Poloxamer on release of poorly water soluble drug Loratadine from solid dispersion: Kneading method
title_fullStr Effect of Poloxamer on release of poorly water soluble drug Loratadine from solid dispersion: Kneading method
title_full_unstemmed Effect of Poloxamer on release of poorly water soluble drug Loratadine from solid dispersion: Kneading method
title_sort effect of poloxamer on release of poorly water soluble drug loratadine from solid dispersion: kneading method
publisher University Ss Cyril and Methodius in Skopje, Faculty of Pharmacy and Macedonian Pharmaceutical Association
series Makedonsko Farmacevtski Bilten
issn 1409-8695
1857-8969
publishDate 2015-05-01
description The main objective of the current study was to enhance the solubility and dissolution of poorly water soluble drug Loratadine (LOR) through formulation of solid dispersion systems (SDs) using hydrophilic polymers. SDs were prepared by kneading method using different drug-to-polymer ratios (1:3 and 1:5) with poloxomer 188 (samples DS1, DS2) and poloxomer 407 (samples DS3, DS4) as hydrophilic polymers. In vitro drug release studies were performed on prepared SDs (DS1-DS4) and compared to pure drug (LOR only, sample DS0). Prepared SDs showed significant improvement in the release profile compared to LOR.
url http://bulletin.mfd.org.mk/volumes/Volume%2061_1/61_1_001.pdf
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