Mefunidone Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice

Mefunidone Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Mice

Idiopathic pulmonary fibrosis (IPF) is one of the most common and devastating interstitial lung diseases with poor prognosis. Currently, few effective drugs are available for IPF. Hence, we sought to explore the role of mefunidone (MFD), a newly synthesized drug developed by our team, in lung fibros...

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Bibliographic Details
Main Authors: Yuanyuan Han, Mao Jiang, Rongling He, Xin Lv, Xiaohua Liao, Yijun He, Fan Zhang, Lingzhi Long, Guoliang Jiang, Zhangzhe Peng, Lijian Tao, Gaoyun Hu, Jie Meng
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
mefunidone
pulmonary fibrosis
apoptosis
epithelial-mesenchymal transition
TGF-β
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.713572/full

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