Involvement of Allosteric Effect and KCa Channels in Crosstalk between β2-Adrenergic and Muscarinic M2 Receptors in Airway Smooth Muscle

Involvement of Allosteric Effect and KCa Channels in Crosstalk between β2-Adrenergic and Muscarinic M2 Receptors in Airway Smooth Muscle

To advance the development of bronchodilators for asthma and chronic obstructive pulmonary disease (COPD), this study was designed to investigate the mechanism of functional antagonism between β2-adrenergic and muscarinic M2 receptors, focusing on allosteric effects and G proteins/ion chann...

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Bibliographic Details
Main Authors: Hiroaki Kume, Osamu Nishiyama, Takaaki Isoya, Yuji Higashimoto, Yuji Tohda, Yukihiro Noda
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
synergistic effects
G protein
large-conductance Ca2+-activated K+ channels
L-type voltage-dependent Ca2+ channels
β2-adrenoceptor agonists
muscarinic receptor antagonists
asthma
COPD
Online Access:http://www.mdpi.com/1422-0067/19/7/1999

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