Empirical examination of the replicability of associations between brain structure and psychological variables

• Main Authors: Shahrzad Kharabian Masouleh, Simon B Eickhoff, Felix Hoffstaedter, Sarah Genon, Alzheimer's Disease Neuroimaging Initiative
• Format: Article
• Language: English
• Published: eLife Sciences Publications Ltd 2019-03-01
• Series: eLife
• Subjects: psychometry; structural brain-behavior associations; inter-individual differences; brain morphometry; replication
• Online Access: https://elifesciences.org/articles/43464

Linking interindividual differences in psychological phenotype to variations in brain structure is an old dream for psychology and a crucial question for cognitive neurosciences. Yet, replicability of the previously-reported ‘structural brain behavior’ (SBB)-associations has been questioned, recently. Here, we conducted an empirical investigation, assessing replicability of SBB among heathy adults. For a wide range of psychological measures, the replicability of associations with gray matter volume was assessed. Our results revealed that among healthy individuals 1) finding an association between performance at standard psychological tests and brain morphology is relatively unlikely 2) significant associations, found using an exploratory approach, have overestimated effect sizes and 3) can hardly be replicated in an independent sample. After considering factors such as sample size and comparing our findings with more replicable SBB-associations in a clinical cohort and replicable associations between brain structure and non-psychological phenotype, we discuss the potential causes and consequences of these findings.