Agnathan VIP, PACAP and their receptors: ancestral origins of today's highly diversified forms.

VIP and PACAP are pleiotropic peptides belonging to the secretin superfamily of brain-gut peptides and interact specifically with three receptors (VPAC(1), PAC(1) and VPAC(2)) from the class II B G protein-coupled receptor family. There is immense interest regarding their molecular evolution which i...

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Bibliographic Details
Main Authors: Stephanie Y L Ng, Billy K C Chow, Jun Kasamatsu, Masanori Kasahara, Leo T O Lee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3434177?pdf=render