Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancer

Abstract Background Studies of cancer mutations have typically focused on identifying cancer driving mutations that confer growth advantage to cancer cells. However, cancer genomes accumulate a large number of passenger somatic mutations resulting from various endogenous and exogenous causes, includ...

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Bibliographic Details
Main Authors: Yoo-Ah Kim, Damian Wojtowicz, Rebecca Sarto Basso, Itay Sason, Welles Robinson, Dorit S. Hochbaum, Mark D. M. Leiserson, Roded Sharan, Fabio Vadin, Teresa M. Przytycka
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Genome Medicine
Subjects:
Mutational signature
Continuous cancer phenotype
Gene network
Network-phenotype association
Breast cancer
APOBEC
Online Access:http://link.springer.com/article/10.1186/s13073-020-00745-2

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