Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective

This review provides an overview on the active phytochemical constituents of medicinal plants that are traditionally used to manage cancer in Ethiopia. A total of 119 articles published between 1968 and 2020 have been reviewed, using scientific search engines such as ScienceDirect, PubMed, and Googl...

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Main Authors:	Solomon Tesfaye, Kaleab Asres, Ermias Lulekal, Yonatan Alebachew, Eyael Tewelde, Mallika Kumarihamy, Ilias Muhammad
Format:	Article
Language:	English
Published:	MDPI AG 2020-09-01
Series:	Molecules
Subjects:	medicinal plants cancer Ethiopia phytochemistry
Online Access:	https://www.mdpi.com/1420-3049/25/17/4032

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spelling	doaj-f01a1cef04c340a8a0c6a65e73ab92a62020-11-25T03:18:30ZengMDPI AGMolecules1420-30492020-09-01254032403210.3390/molecules25174032Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future PerspectiveSolomon Tesfaye0Kaleab Asres1Ermias Lulekal2Yonatan Alebachew3Eyael Tewelde4Mallika Kumarihamy5Ilias Muhammad6School of Pharmacy, College of Health Sciences, Addis Ababa University, Churchill Street, 1176 Addis Ababa, EthiopiaSchool of Pharmacy, College of Health Sciences, Addis Ababa University, Churchill Street, 1176 Addis Ababa, EthiopiaDepartment of Plant Biology and Biodiversity Management, College of Natural and Computational Sciences, The National Herbarium, Addis Ababa University, 34731 Addis Ababa, EthiopiaSchool of Pharmacy, College of Health Sciences, Addis Ababa University, Churchill Street, 1176 Addis Ababa, EthiopiaSchool of Pharmacy, College of Health Sciences, Addis Ababa University, Churchill Street, 1176 Addis Ababa, EthiopiaNational Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USANational Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USAThis review provides an overview on the active phytochemical constituents of medicinal plants that are traditionally used to manage cancer in Ethiopia. A total of 119 articles published between 1968 and 2020 have been reviewed, using scientific search engines such as ScienceDirect, PubMed, and Google Scholar. Twenty-seven medicinal plant species that belong to eighteen families are documented along with their botanical sources, potential active constituents, and in vitro and in vivo activities against various cancer cells. The review is compiled and discusses the potential anticancer, antiproliferative, and cytotoxic agents based on the types of secondary metabolites, such as terpenoids, phenolic compounds, alkaloids, steroids, and lignans. Among the anticancer secondary metabolites reported in this review, only few have been isolated from plants that are originated and collected in Ethiopia, and the majority of compounds are reported from plants belonging to different areas of the world. Thus, based on the available bioactivity reports, extensive and more elaborate ethnopharmacology-based bioassay-guided studies have to be conducted on selected traditionally claimed Ethiopian anticancer plants, which inherited from a unique and diverse landscape, with the aim of opening a way forward to conduct anticancer drug discovery program.https://www.mdpi.com/1420-3049/25/17/4032medicinal plantscancerEthiopiaphytochemistry
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Solomon Tesfaye Kaleab Asres Ermias Lulekal Yonatan Alebachew Eyael Tewelde Mallika Kumarihamy Ilias Muhammad
spellingShingle	Solomon Tesfaye Kaleab Asres Ermias Lulekal Yonatan Alebachew Eyael Tewelde Mallika Kumarihamy Ilias Muhammad Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective Molecules medicinal plants cancer Ethiopia phytochemistry
author_facet	Solomon Tesfaye Kaleab Asres Ermias Lulekal Yonatan Alebachew Eyael Tewelde Mallika Kumarihamy Ilias Muhammad
author_sort	Solomon Tesfaye
title	Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective
title_short	Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective
title_full	Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective
title_fullStr	Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective
title_full_unstemmed	Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective
title_sort	ethiopian medicinal plants traditionally used for the treatment of cancer, part 2: a review on cytotoxic, antiproliferative, and antitumor phytochemicals, and future perspective
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2020-09-01
description	This review provides an overview on the active phytochemical constituents of medicinal plants that are traditionally used to manage cancer in Ethiopia. A total of 119 articles published between 1968 and 2020 have been reviewed, using scientific search engines such as ScienceDirect, PubMed, and Google Scholar. Twenty-seven medicinal plant species that belong to eighteen families are documented along with their botanical sources, potential active constituents, and in vitro and in vivo activities against various cancer cells. The review is compiled and discusses the potential anticancer, antiproliferative, and cytotoxic agents based on the types of secondary metabolites, such as terpenoids, phenolic compounds, alkaloids, steroids, and lignans. Among the anticancer secondary metabolites reported in this review, only few have been isolated from plants that are originated and collected in Ethiopia, and the majority of compounds are reported from plants belonging to different areas of the world. Thus, based on the available bioactivity reports, extensive and more elaborate ethnopharmacology-based bioassay-guided studies have to be conducted on selected traditionally claimed Ethiopian anticancer plants, which inherited from a unique and diverse landscape, with the aim of opening a way forward to conduct anticancer drug discovery program.
topic	medicinal plants cancer Ethiopia phytochemistry
url	https://www.mdpi.com/1420-3049/25/17/4032
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Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer, Part 2: A Review on Cytotoxic, Antiproliferative, and Antitumor Phytochemicals, and Future Perspective

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