Siah2 modulates sex-dependent metabolic and inflammatory responses in adipose tissue to a high-fat diet challenge

Siah2 modulates sex-dependent metabolic and inflammatory responses in adipose tissue to a high-fat diet challenge

Abstract Background The obesity-related risk of developing metabolic syndrome is higher in males than in females of reproductive age, likely due to estrogen-mediated reduced adipose tissue inflammation and fibrosis with hypertrophied adipocytes. Depletion of the ubiquitin ligase Siah2 reduced white...

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Bibliographic Details
Main Authors: Sujoy Ghosh, Jessica L. Taylor, Tamra M. Mendoza, Thanh Dang, David H. Burk, Yongmei Yu, Gail Kilroy, Z. Elizabeth Floyd
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Biology of Sex Differences
Subjects:
Adipose tissue
Estrogen
Estrogen receptor
Estrogen-related receptor
Inflammation
Obesity
Online Access:http://link.springer.com/article/10.1186/s13293-019-0233-y

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http://link.springer.com/article/10.1186/s13293-019-0233-y

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