DESE: estimating driver tissues by selective expression of genes associated with complex diseases or traits

DESE: estimating driver tissues by selective expression of genes associated with complex diseases or traits

Abstract The driver tissues or cell types in which susceptibility genes initiate diseases remain elusive. We develop a unified framework to detect the causal tissues of complex diseases or traits according to selective expression of disease-associated genes in genome-wide association studies (GWASs)...

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Bibliographic Details
Main Authors: Lin Jiang, Chao Xue, Sheng Dai, Shangzhen Chen, Peikai Chen, Pak Chung Sham, Haijun Wang, Miaoxin Li
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Genome Biology
Subjects:
Tissue-selective expression
Disease driver-tissues
Susceptibility genes
Gene-based association
Genome-wide association study
Online Access:http://link.springer.com/article/10.1186/s13059-019-1801-5

Internet

http://link.springer.com/article/10.1186/s13059-019-1801-5

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