Lipid A Has Significance for Optimal Growth of Coxiella burnetii in Macrophage-Like THP-1 Cells and to a Lesser Extent in Axenic Media and Non-phagocytic Cells

Lipid A Has Significance for Optimal Growth of Coxiella burnetii in Macrophage-Like THP-1 Cells and to a Lesser Extent in Axenic Media and Non-phagocytic Cells

Lipid A is an essential basal component of lipopolysaccharide of most Gram-negative bacteria. Inhibitors targeting LpxC, a conserved enzyme in lipid A biosynthesis, are antibiotic candidates against Gram-negative pathogens. Here we report the characterization of the role of lipid A in Coxiella burne...

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Bibliographic Details
Main Authors: Tao Wang, Yonghui Yu, Xiaofei Liang, Shengdong Luo, Zemin He, Zhihui Sun, Yongqiang Jiang, Anders Omsland, Pei Zhou, Lihua Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Q fever
Coxiella burnetii
LpxC inhibitor
LPC-011
lipid A
LPS
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2018.00192/full

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