CO2-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic culture

CO2-evoked release of PGE2 modulates sighs and inspiration as demonstrated in brainstem organotypic culture

Inflammation-induced release of prostaglandin E2 (PGE2) changes breathing patterns and the response to CO2 levels. This may have fatal consequences in newborn babies and result in sudden infant death. To elucidate the underlying mechanisms, we present a novel breathing brainstem organotypic culture...

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Bibliographic Details
Main Authors: David Forsberg, Zachi Horn, Evangelia Tserga, Erik Smedler, Gilad Silberberg, Yuri Shvarev, Kai Kaila, Per Uhlén, Eric Herlenius
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
respiration
prostaglandins
neural network
chemosensitivity
calcium imaging
small world
Online Access:https://elifesciences.org/articles/14170

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