Description of 3 Cases in Vietnam of Aspirin Desensitization in Patients With Coronary Artery Disease and Coexisting Aspirin Hypersensitivity

Description of 3 Cases in Vietnam of Aspirin Desensitization in Patients With Coronary Artery Disease and Coexisting Aspirin Hypersensitivity

Aspirin (ASA) hypersensitivity comprises types I to III (Cox-1 mediated) and types IV and V (IgE antibody mediated). Rapid, low-dose (81-325 mg/day) ASA desensitization regimens are known to be useful in establishing ASA tolerance in patients with coronary artery disease and coexisting ASA/nonsteroi...

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Main Authors: Dinh Van Nguyen, MD, Hieu Chu Chi, MD, Doan Van Nguyen, MD, PhD, Timothy J. Craig, DO, Sheryl van Nunen, MB, BS, MM, FRACP
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:World Allergy Organization Journal
Online Access:http://www.sciencedirect.com/science/article/pii/S1939455119303977
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spelling doaj-effbd7ed3a514b228dc7f5c9c3751c662020-11-25T01:52:44ZengElsevierWorld Allergy Organization Journal1939-45512012-01-01511170173Description of 3 Cases in Vietnam of Aspirin Desensitization in Patients With Coronary Artery Disease and Coexisting Aspirin HypersensitivityDinh Van Nguyen, MD0Hieu Chu Chi, MD1Doan Van Nguyen, MD, PhD2Timothy J. Craig, DO3Sheryl van Nunen, MB, BS, MM, FRACP4Allergy Department, Hanoi Medical University, Hanoi, Vietnam;; Center of Allergology and Clinical Immunology, Bach Mai Hospital, Hanoi, Vietnam;; Corresponding author.Center of Allergology and Clinical Immunology, Bach Mai Hospital, Hanoi, Vietnam;Allergy Department, Hanoi Medical University, Hanoi, Vietnam;; Center of Allergology and Clinical Immunology, Bach Mai Hospital, Hanoi, Vietnam;Section of Allergy, Asthma and Immunology, Pennsylvania State University, Hershey, PA;Sydney Medical School-Northern, University of Sydney, Sydney, Australia;; Department of Clinical Immunology and Allergy, Royal North Shore Hospital, Sydney, Australia.Aspirin (ASA) hypersensitivity comprises types I to III (Cox-1 mediated) and types IV and V (IgE antibody mediated). Rapid, low-dose (81-325 mg/day) ASA desensitization regimens are known to be useful in establishing ASA tolerance in patients with coronary artery disease and coexisting ASA/nonsteroidal anti-inflammatory drug hypersensitivity. We document 3 cases in Vietnam of desensitization to ASA in patients with coronary artery disease and coexisting ASA hypersensitivity. One of these 3 patients had probable immune-mediated hypersensitivity, whereas the remaining 2 had probable Cox-1-mediated reactions. The regimen of desensitization we employed for each patient was designed to account for the probable mechanism of hypersensitivity in the individual and further modified according to the degree of tolerance observed, with all 3 patients eventually achieving a daily cardioprotective dosage of ASA. Keywords: Vietnam, aspirin (ASA) hypersensitivity, ASA desensitization, coronary artery diseasehttp://www.sciencedirect.com/science/article/pii/S1939455119303977
collection DOAJ
language English
format Article
sources DOAJ
author Dinh Van Nguyen, MD
Hieu Chu Chi, MD
Doan Van Nguyen, MD, PhD
Timothy J. Craig, DO
Sheryl van Nunen, MB, BS, MM, FRACP
spellingShingle Dinh Van Nguyen, MD
Hieu Chu Chi, MD
Doan Van Nguyen, MD, PhD
Timothy J. Craig, DO
Sheryl van Nunen, MB, BS, MM, FRACP
Description of 3 Cases in Vietnam of Aspirin Desensitization in Patients With Coronary Artery Disease and Coexisting Aspirin Hypersensitivity
World Allergy Organization Journal
author_facet Dinh Van Nguyen, MD
Hieu Chu Chi, MD
Doan Van Nguyen, MD, PhD
Timothy J. Craig, DO
Sheryl van Nunen, MB, BS, MM, FRACP
author_sort Dinh Van Nguyen, MD
title Description of 3 Cases in Vietnam of Aspirin Desensitization in Patients With Coronary Artery Disease and Coexisting Aspirin Hypersensitivity
title_short Description of 3 Cases in Vietnam of Aspirin Desensitization in Patients With Coronary Artery Disease and Coexisting Aspirin Hypersensitivity
title_full Description of 3 Cases in Vietnam of Aspirin Desensitization in Patients With Coronary Artery Disease and Coexisting Aspirin Hypersensitivity
title_fullStr Description of 3 Cases in Vietnam of Aspirin Desensitization in Patients With Coronary Artery Disease and Coexisting Aspirin Hypersensitivity
title_full_unstemmed Description of 3 Cases in Vietnam of Aspirin Desensitization in Patients With Coronary Artery Disease and Coexisting Aspirin Hypersensitivity
title_sort description of 3 cases in vietnam of aspirin desensitization in patients with coronary artery disease and coexisting aspirin hypersensitivity
publisher Elsevier
series World Allergy Organization Journal
issn 1939-4551
publishDate 2012-01-01
description Aspirin (ASA) hypersensitivity comprises types I to III (Cox-1 mediated) and types IV and V (IgE antibody mediated). Rapid, low-dose (81-325 mg/day) ASA desensitization regimens are known to be useful in establishing ASA tolerance in patients with coronary artery disease and coexisting ASA/nonsteroidal anti-inflammatory drug hypersensitivity. We document 3 cases in Vietnam of desensitization to ASA in patients with coronary artery disease and coexisting ASA hypersensitivity. One of these 3 patients had probable immune-mediated hypersensitivity, whereas the remaining 2 had probable Cox-1-mediated reactions. The regimen of desensitization we employed for each patient was designed to account for the probable mechanism of hypersensitivity in the individual and further modified according to the degree of tolerance observed, with all 3 patients eventually achieving a daily cardioprotective dosage of ASA. Keywords: Vietnam, aspirin (ASA) hypersensitivity, ASA desensitization, coronary artery disease
url http://www.sciencedirect.com/science/article/pii/S1939455119303977
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