MiDRM<i>pol</i>: A High-Throughput Multiplexed Amplicon Sequencing Workflow to Quantify HIV-1 Drug Resistance Mutations against Protease, Reverse Transcriptase, and Integrase Inhibitors

MiDRM<i>pol</i>: A High-Throughput Multiplexed Amplicon Sequencing Workflow to Quantify HIV-1 Drug Resistance Mutations against Protease, Reverse Transcriptase, and Integrase Inhibitors

The detection of drug resistance mutations (DRMs) in minor viral populations is of potential clinical importance. However, sophisticated computational infrastructure and competence for analysis of high-throughput sequencing (HTS) data lack at most diagnostic laboratories. Thus, we have proposed a ne...

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Bibliographic Details
Main Authors: Shambhu G. Aralaguppe, Anoop T. Ambikan, Manickam Ashokkumar, Milner M. Kumar, Luke Elizabeth Hanna, Wondwossen Amogne, Anders Sönnerborg, Ujjwal Neogi
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Viruses
Subjects:
MiDRM<i>pol</i>
high-throughput sequencing
drug resistance mutation
antiretroviral therapy
surveillance
Online Access:https://www.mdpi.com/1999-4915/11/9/806

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