The transcriptional elongation rate regulates alternative polyadenylation in yeast

The transcriptional elongation rate regulates alternative polyadenylation in yeast

Yeast cells undergoing the diauxic response show a striking upstream shift in poly(A) site utilization, with increased use of ORF-proximal poly(A) sites resulting in shorter 3’ mRNA isoforms for most genes. This altered poly(A) pattern is extremely similar to that observed in cells containing Pol II...

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Bibliographic Details
Main Authors: Joseph V Geisberg, Zarmik Moqtaderi, Kevin Struhl
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-08-01
Series:eLife
Subjects:
polyadenylation
transcription elongation
RNA polymerase II
gene expression
gene regulation
Online Access:https://elifesciences.org/articles/59810

Internet

https://elifesciences.org/articles/59810

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