Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer

Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer

Acquired resistance to chemotherapy can lead to multi-drug resistance and poor prognosis in cancer. Here, the authors show that Rac1 increases glycolysis and non-oxidative pentose phosphate pathway activity leading to neoadjuvant chemotherapy (NAC) resistance, thus its inhibition sensitizes resistan...

Full description

Bibliographic Details
Main Authors: Qingjian Li, Tao Qin, Zhuofei Bi, Huangming Hong, Lin Ding, Jiewen Chen, Wei Wu, Xiaorong Lin, Wenkui Fu, Fang Zheng, Yandan Yao, Man-Li Luo, Phei Er Saw, Gerburg M. Wulf, Xiaoding Xu, Erwei Song, Herui Yao, Hai Hu
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15308-7

Internet

https://doi.org/10.1038/s41467-020-15308-7

Similar Items