Primary Exophytic Extraskeletal Osteosarcoma of the Liver: A Case Report and Literature Review

• Main Authors: Zhang J, He X, Yu W, Ying F, Cai J, Deng S
• Format: Article
• Language: English
• Published: Dove Medical Press 2021-03-01
• Series: Risk Management and Healthcare Policy
• Subjects: extraskeletal; osteosarcoma; hepatic; tumor bone; primary
• Online Access: https://www.dovepress.com/primary-exophytic-extraskeletal-osteosarcoma-of-the-liver-a-case-repor-peer-reviewed-article-RMHP

Jing Zhang,1 Xiuchao He,1 Wenying Yu,2 Fuming Ying,3 Jun Cai,4 Shengde Deng1 1Department of Imaging Center, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, Zhejiang Province, 315000, People’s Republic of China; 2Ningbo Diagnostic Pathology Center, Ningbo, Zhejiang Province, 315000, People’s Republic of China; 3Department of Hepatobiliary Surgery, The Affiliated Hospital of Medical School of Ningbo University, Ningbo, Zhejiang Province, 315000, People’s Republic of China; 4Department of PET-CT Diagnosis Center, Mingzhou Hospital of Zhejiang University, Ningbo, Zhejiang Province, 315000, People’s Republic of ChinaCorrespondence: Shengde DengDepartment of Imaging Center, The Affiliated Hospital of Medical School of Ningbo University, No. 247 of Renmin Street, Jiangbei District, Ningbo, Zhejiang Province, 315000, People’s Republic of ChinaTel/Fax [phone]Email [e-mail]: Primary hepatic extraskeletal osteosarcoma (ESOS) is a rare tumor with no specific clinical manifestations, and little is known about it. Here, we describe an elderly patient with primary hepatic osteosarcoma confirmed by pathology results to raise awareness.Case Report: We report an unusual case of a 62-year-old man who presented with right upper quadrant pain. The inflammatory indicators were elevated, and alkaline phosphatase (AKP), carbohydrate antigen (CA-199 and CA-125) were slightly increased. Computed tomography images and magnetic resonance images discovered a 7.8 × 7.4 × 6.6 cm mass with irregular radiated and cotton-like tumor bone between the liver and right kidney space. Pathology revealed the mass to be primary exophytic ESOS of the liver. The patient underwent a surgical operation and standard chemotherapy and is still alive with no recurrence and metastasis to date.Conclusion: Owing to the rarity of the tumor and the lack of clinical characteristics and specific laboratory indexes, it is difficult to make a correct diagnosis. Medical imaging features mainly behave soft tissue entity with tumor bone composition. Surgical resection combined with adjuvant chemotherapy is the main treatment for ESOS.Keywords: extraskeletal, osteosarcoma, hepatic, tumor bone, primary