COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function

COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function

<p>Abstract</p> <p>Background</p> <p>Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature cells that accumulates in tumour-bearing hosts. These cells are induced by tumour-derived factors (e.g. prostaglandins) and have a critical role in im...

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Bibliographic Details
Main Authors: Veltman Joris D, Lambers Margaretha EH, van Nimwegen Menno, Hendriks Rudi W, Hoogsteden Henk C, Aerts Joachim GJV, Hegmans Joost PJJ
Format: Article
Language:English
Published: BMC 2010-08-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/10/464

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