Case Report: Myelin Oligodendrocyte Glycoprotein Antibody-Associated Relapse With COVID-19

• Main Authors: Mark Woodhall, James W. Mitchell, Emily Gibbons, Sarah Healy, Patrick Waters, Saif Huda
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2020-11-01
• Series: Frontiers in Neurology
• Subjects: myelin-oligodendrocyte glycoprotein (MOG); optic neuritis; Devic's disease; visual loss; post-infectious; autoimmune diseases
• Online Access: https://www.frontiersin.org/articles/10.3389/fneur.2020.598531/full
• ISSN: 1664-2295

A 39-year-old lady with relapsing myelin oligodendrocyte glycoprotein antibody (MOG-IgG) associated disease developed coryzal symptoms, malaise, sweating, and postural dizziness. Six days later she presented with painful progressive right visual loss consistent with optic neuritis. COVID-19 was confirmed by nasopharyngeal swab and MOG-IgG serological reversion was noted. Visual function improved following steroids and plasma exchange. This case highlights a possible causal association between inflammation due to COVID-19 and a relapse of MOG-IgG associated disease. It also highlights the clinical relevance of reporting MOG-IgG titers in MOG-IgG associated disease.