Viral Cre-LoxP tools aid genome engineering in mammalian cells

Viral Cre-LoxP tools aid genome engineering in mammalian cells

Abstract Background Targeted nucleases have transformed genome editing technology, providing more efficient methods to make targeted changes in mammalian genome. In parallel, there is an increasing demand of Cre-LoxP technology for complex genome manipulation such as large deletion, addition, gene f...

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Bibliographic Details
Main Authors: Ranjita Sengupta, Amy Mendenhall, Nandita Sarkar, Chandreyee Mukherjee, Amirali Afshari, Joseph Huang, Biao Lu
Format: Article
Language:English
Published: BMC 2017-11-01
Series:Journal of Biological Engineering
Subjects:
Cre-LoxP
Cre recombinase
Lentiviral vector
AAV vector
Genome editing
Talen
Online Access:http://link.springer.com/article/10.1186/s13036-017-0087-y

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http://link.springer.com/article/10.1186/s13036-017-0087-y

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