EZH1 and EZH2 promote skeletal growth by repressing inhibitors of chondrocyte proliferation and hypertrophy
EZH1 and EZH2 are associated with epigenetic bone and cartilage developmental defects. Here the authors show that cartilage-specific double knockout mice have reduced skeletal growth and how these histone methyltransferases regulate chondrogenesis and endochondral bone development.
Bibliographic Details
| Main Authors: |
Julian C. Lui,
Presley Garrison,
Quang Nguyen,
Michal Ad,
Chithra Keembiyehetty,
Weiping Chen,
Youn Hee Jee,
Ellie Landman,
Ola Nilsson,
Kevin M. Barnes,
Jeffrey Baron |
|---|
| Format: | Article
|
|---|
| Language: | English |
|---|
| Published: |
Nature Publishing Group
2016-11-01
|
|---|
| Series: | Nature Communications
|
|---|
| Online Access: | https://doi.org/10.1038/ncomms13685
|
|---|
