Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicella-zoster virus.

Entrapment of viral capsids in nuclear PML cages is an intrinsic antiviral host defense against varicella-zoster virus.

The herpesviruses, like most other DNA viruses, replicate in the host cell nucleus. Subnuclear domains known as promyelocytic leukemia protein nuclear bodies (PML-NBs), or ND10 bodies, have been implicated in restricting early herpesviral gene expression. These viruses have evolved countermeasures t...

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Bibliographic Details
Main Authors: Mike Reichelt, Li Wang, Marvin Sommer, John Perrino, Adel M Nour, Nandini Sen, Armin Baiker, Leigh Zerboni, Ann M Arvin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3033373?pdf=render

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