The Relationship between Weight as Well as the Kind of Prostate Hypertrophy and the Response to Tamsulosine, a Specific ?-Blocker

• Main Author: Hayat Mombini
• Format: Article
• Language: English
• Published: Urology and Nephrology Research Center, Shahid Beheshti University of Medical Sciences 2004-06-01
• Series: Urology Journal
• Online Access: http://www.urologyjournal.org/index.php/uj/article/view/341/335
• ISSN: 1735-1308; 1735-546X

<p class="MsoNormal" style="margin: 0cm 0cm 0pt; direction: ltr; unicode-bidi: embed; text-align: left;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong>Purpose:</strong> To study the effects of Tamsulosine (Flowmax) as a specific ?-blocker in patients with prostate weighted less than 40 g and lacked median lobe and to compare them to patients with prostate weighted more than 40 g with median lobe.</span></span></p><p class="MsoNormal" style="margin: 0cm 0cm 0pt; direction: ltr; unicode-bidi: embed; text-align: left;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong>Materials and Methods:</strong> Forty outpatients with BPH were referred to clinic and intentionally enrolled in this study. Patients were divided into 2 groups of 20 patients. Tamsulosine was daily administered for all of them for 6 weeks. Routine tests were performed for all patients, all of which were normal. The probability of prostate cancer was ruled out. The size of prostate and type of hypertrophy were determined by one radiologist via DRE, suprapubic ultrasonography and TRUS-P. Patients were divided into A and B groups according to the size of prostate and the lack of median lobe or its presence. Prostate size was less than 40 mg in group A and all patients lacked median lobe; whereas, prostate size was more than 40 mg (between 40-60 mg) in group B and patients had some median lobe.</span></span></p><p class="MsoNormal" style="margin: 0cm 0cm 0pt; direction: ltr; unicode-bidi: embed; text-align: left;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong>Results:</strong> An increase of 30% in base line Q Max and a decrease of 25% in base line IPSS was seen in 16 patients (80%) of group A, while these were observed only 9 patients (45%) of group B. </span></span></p><p class="MsoNormal" style="margin: 0cm 0cm 0pt; direction: ltr; unicode-bidi: embed; text-align: left;"><span style="font-size: small;"><span style="font-family: Times New Roman;"><strong>Conclusion:</strong> Determination of prostate size and the type of hypertrophy seems to be essential before any Tamsulosine administration. The weight of prostate is determined by protoscan.</span></span></p>