Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation

Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation

Bacterial pathogens can subvert host cell processes through secreted proteins but the precise mechanisms and repertoire of proteins remains unclear. Here the authors report that a bacterial effector protein of Xanthomonas campestris, XopR, undergoes liquid-liquid phase separation to hijack the host...

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Main Authors: He Sun, Xinlu Zhu, Chuanxi Li, Zhiming Ma, Xiao Han, Yuanyuan Luo, Liang Yang, Jing Yu, Yansong Miao
Format: Article
Language:English
Published: Nature Publishing Group 2021-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24375-3
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spelling doaj-ef70eee850ae42c0b70d58ce409f549b2021-07-04T11:45:25ZengNature Publishing GroupNature Communications2041-17232021-07-0112111710.1038/s41467-021-24375-3Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervationHe Sun0Xinlu Zhu1Chuanxi Li2Zhiming Ma3Xiao Han4Yuanyuan Luo5Liang Yang6Jing Yu7Yansong Miao8School of Biological Sciences, Nanyang Technological UniversitySchool of Biological Sciences, Nanyang Technological UniversitySchool of Materials Science and Engineering, Nanyang Technological UniversitySchool of Biological Sciences, Nanyang Technological UniversitySchool of Biological Sciences, Nanyang Technological UniversitySchool of Biological Sciences, Nanyang Technological UniversitySchool of Biological Sciences, Nanyang Technological UniversitySchool of Materials Science and Engineering, Nanyang Technological UniversitySchool of Biological Sciences, Nanyang Technological UniversityBacterial pathogens can subvert host cell processes through secreted proteins but the precise mechanisms and repertoire of proteins remains unclear. Here the authors report that a bacterial effector protein of Xanthomonas campestris, XopR, undergoes liquid-liquid phase separation to hijack the host cell actin cytoskeleton.https://doi.org/10.1038/s41467-021-24375-3
collection DOAJ
language English
format Article
sources DOAJ
author He Sun
Xinlu Zhu
Chuanxi Li
Zhiming Ma
Xiao Han
Yuanyuan Luo
Liang Yang
Jing Yu
Yansong Miao
spellingShingle He Sun
Xinlu Zhu
Chuanxi Li
Zhiming Ma
Xiao Han
Yuanyuan Luo
Liang Yang
Jing Yu
Yansong Miao
Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation
Nature Communications
author_facet He Sun
Xinlu Zhu
Chuanxi Li
Zhiming Ma
Xiao Han
Yuanyuan Luo
Liang Yang
Jing Yu
Yansong Miao
author_sort He Sun
title Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation
title_short Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation
title_full Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation
title_fullStr Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation
title_full_unstemmed Xanthomonas effector XopR hijacks host actin cytoskeleton via complex coacervation
title_sort xanthomonas effector xopr hijacks host actin cytoskeleton via complex coacervation
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-07-01
description Bacterial pathogens can subvert host cell processes through secreted proteins but the precise mechanisms and repertoire of proteins remains unclear. Here the authors report that a bacterial effector protein of Xanthomonas campestris, XopR, undergoes liquid-liquid phase separation to hijack the host cell actin cytoskeleton.
url https://doi.org/10.1038/s41467-021-24375-3
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AT xinluzhu xanthomonaseffectorxoprhijackshostactincytoskeletonviacomplexcoacervation
AT chuanxili xanthomonaseffectorxoprhijackshostactincytoskeletonviacomplexcoacervation
AT zhimingma xanthomonaseffectorxoprhijackshostactincytoskeletonviacomplexcoacervation
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