Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

<p>Abstract</p> <p>Background</p> <p>Tyrosine kinase 2 (Tyk2), a central component of Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling, has major effects on innate immunity and inflammation. Mice lacking Tyk2 are resistant to endotoxin...

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Bibliographic Details
Main Authors: Kovarik Pavel, Stiefvater Rita, Wallner Barbara, Hofmann Elisabeth, Fuhrmann Bernd, Flatt Thomas, Vogl Claus, Strobl Birgit, Müller Mathias
Format: Article
Language:English
Published: BMC 2010-03-01
Series:BMC Genomics
Online Access:http://www.biomedcentral.com/1471-2164/11/199

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http://www.biomedcentral.com/1471-2164/11/199

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