Molecular insights into antibiotic resistance - how a binding protein traps albicidin

Molecular insights into antibiotic resistance - how a binding protein traps albicidin

The potent antibacterial compound albicidin is synthesized by the plant-pathogenic bacterium Xanthomonas albilineans. Here the authors employ a multidisciplinary approach and provide structural and mechanistic insights into how the drug-binding protein AlbA confers albicidin resistance to Klebsiella...

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Main Authors: Lida Rostock, Ronja Driller, Stefan Grätz, Dennis Kerwat, Leonard von Eckardstein, Daniel Petras, Maria Kunert, Claudia Alings, Franz-Josef Schmitt, Thomas Friedrich, Markus C. Wahl, Bernhard Loll, Andi Mainz, Roderich D. Süssmuth
Format: Article
Language:English
Published: Nature Publishing Group 2018-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-05551-4
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spelling doaj-ef5cd126b6d942939a1a01e88363268b2021-05-11T10:28:05ZengNature Publishing GroupNature Communications2041-17232018-08-019111310.1038/s41467-018-05551-4Molecular insights into antibiotic resistance - how a binding protein traps albicidinLida Rostock0Ronja Driller1Stefan Grätz2Dennis Kerwat3Leonard von Eckardstein4Daniel Petras5Maria Kunert6Claudia Alings7Franz-Josef Schmitt8Thomas Friedrich9Markus C. Wahl10Bernhard Loll11Andi Mainz12Roderich D. Süssmuth13Institut für Chemie, Biologische Chemie, Technische Universität BerlinInstitut für Chemie und Biochemie, Strukturbiochemie, Freie Universität BerlinInstitut für Chemie, Biologische Chemie, Technische Universität BerlinInstitut für Chemie, Biologische Chemie, Technische Universität BerlinInstitut für Chemie, Biologische Chemie, Technische Universität BerlinInstitut für Chemie, Biologische Chemie, Technische Universität BerlinInstitut für Chemie, Biologische Chemie, Technische Universität BerlinInstitut für Chemie und Biochemie, Strukturbiochemie, Freie Universität BerlinInstitut für Chemie, Biophysikalische Chemie, Technische Universität BerlinInstitut für Chemie, Biophysikalische Chemie, Technische Universität BerlinInstitut für Chemie und Biochemie, Strukturbiochemie, Freie Universität BerlinInstitut für Chemie und Biochemie, Strukturbiochemie, Freie Universität BerlinInstitut für Chemie, Biologische Chemie, Technische Universität BerlinInstitut für Chemie, Biologische Chemie, Technische Universität BerlinThe potent antibacterial compound albicidin is synthesized by the plant-pathogenic bacterium Xanthomonas albilineans. Here the authors employ a multidisciplinary approach and provide structural and mechanistic insights into how the drug-binding protein AlbA confers albicidin resistance to Klebsiella oxytoca.https://doi.org/10.1038/s41467-018-05551-4
collection DOAJ
language English
format Article
sources DOAJ
author Lida Rostock
Ronja Driller
Stefan Grätz
Dennis Kerwat
Leonard von Eckardstein
Daniel Petras
Maria Kunert
Claudia Alings
Franz-Josef Schmitt
Thomas Friedrich
Markus C. Wahl
Bernhard Loll
Andi Mainz
Roderich D. Süssmuth
spellingShingle Lida Rostock
Ronja Driller
Stefan Grätz
Dennis Kerwat
Leonard von Eckardstein
Daniel Petras
Maria Kunert
Claudia Alings
Franz-Josef Schmitt
Thomas Friedrich
Markus C. Wahl
Bernhard Loll
Andi Mainz
Roderich D. Süssmuth
Molecular insights into antibiotic resistance - how a binding protein traps albicidin
Nature Communications
author_facet Lida Rostock
Ronja Driller
Stefan Grätz
Dennis Kerwat
Leonard von Eckardstein
Daniel Petras
Maria Kunert
Claudia Alings
Franz-Josef Schmitt
Thomas Friedrich
Markus C. Wahl
Bernhard Loll
Andi Mainz
Roderich D. Süssmuth
author_sort Lida Rostock
title Molecular insights into antibiotic resistance - how a binding protein traps albicidin
title_short Molecular insights into antibiotic resistance - how a binding protein traps albicidin
title_full Molecular insights into antibiotic resistance - how a binding protein traps albicidin
title_fullStr Molecular insights into antibiotic resistance - how a binding protein traps albicidin
title_full_unstemmed Molecular insights into antibiotic resistance - how a binding protein traps albicidin
title_sort molecular insights into antibiotic resistance - how a binding protein traps albicidin
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-08-01
description The potent antibacterial compound albicidin is synthesized by the plant-pathogenic bacterium Xanthomonas albilineans. Here the authors employ a multidisciplinary approach and provide structural and mechanistic insights into how the drug-binding protein AlbA confers albicidin resistance to Klebsiella oxytoca.
url https://doi.org/10.1038/s41467-018-05551-4
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