Anti-Tumor Immunity in Head and Neck Cancer: Understanding the Evidence, How Tumors Escape and Immunotherapeutic Approaches

Anti-Tumor Immunity in Head and Neck Cancer: Understanding the Evidence, How Tumors Escape and Immunotherapeutic Approaches

Many carcinogen- and human papilloma virus (HPV)-associated head and neck cancers (HNSCC) display a hematopoietic cell infiltrate indicative of a T-cell inflamed phenotype and an underlying anti-tumor immune response. However, by definition, these tumors have escaped immune elimination and formed a...

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Bibliographic Details
Main Authors: Clint T. Allen, Paul E. Clavijo, Carter Van Waes, Zhong Chen
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Cancers
Subjects:
syngeneic mouse models
tumor antigen
innate immunity
adaptive immunity
immunosuppression
immunogenicity
antigenicity
checkpoint inhibitors
vaccines
immunotherapy
Online Access:http://www.mdpi.com/2072-6694/7/4/0900

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