Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila
Insulin and insulin-growth-factor-like signaling (IIS) plays important roles in the regulation of development, growth, metabolic homeostasis, and aging, as well as in brain functions such as learning and memory. The temporal-spatial role of IIS in learning and memory and its effect on age-dependent...
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2017-02-01
|
Series: | Cell Reports |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124717301109 |
id |
doaj-ef455cf0b69f4e7c9844541ab78a0d46 |
---|---|
record_format |
Article |
spelling |
doaj-ef455cf0b69f4e7c9844541ab78a0d462020-11-25T01:49:09ZengElsevierCell Reports2211-12472017-02-011871598160510.1016/j.celrep.2017.01.053Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in DrosophilaKento Tanabe0Motoyuki Itoh1Ayako Tonoki2Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, JapanGraduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, JapanGraduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, JapanInsulin and insulin-growth-factor-like signaling (IIS) plays important roles in the regulation of development, growth, metabolic homeostasis, and aging, as well as in brain functions such as learning and memory. The temporal-spatial role of IIS in learning and memory and its effect on age-dependent memory impairment remain unclear. Here, we report that intermediate-term memory (ITM), but not short-term memory (STM), in Drosophila aversive olfactory memory requires transient IIS during adulthood. The expression of Drosophila insulin-like peptide 3 (Dilp3) in insulin-producing cells and insulin receptor function in the fat body are essential for ITM. Although the expression of dilp3 decreases with aging, which is unique among dilp genes, the transient expression of dilp3 in aged flies enhances ITM. These findings indicate that ITM is systemically regulated by communication between insulin-producing cells and fat body and that age-dependent changes in IIS contribute to age-related memory impairment.http://www.sciencedirect.com/science/article/pii/S2211124717301109insulin signalinglearning and memoryagingfat bodyDrosophila |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kento Tanabe Motoyuki Itoh Ayako Tonoki |
spellingShingle |
Kento Tanabe Motoyuki Itoh Ayako Tonoki Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila Cell Reports insulin signaling learning and memory aging fat body Drosophila |
author_facet |
Kento Tanabe Motoyuki Itoh Ayako Tonoki |
author_sort |
Kento Tanabe |
title |
Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila |
title_short |
Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila |
title_full |
Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila |
title_fullStr |
Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila |
title_full_unstemmed |
Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila |
title_sort |
age-related changes in insulin-like signaling lead to intermediate-term memory impairment in drosophila |
publisher |
Elsevier |
series |
Cell Reports |
issn |
2211-1247 |
publishDate |
2017-02-01 |
description |
Insulin and insulin-growth-factor-like signaling (IIS) plays important roles in the regulation of development, growth, metabolic homeostasis, and aging, as well as in brain functions such as learning and memory. The temporal-spatial role of IIS in learning and memory and its effect on age-dependent memory impairment remain unclear. Here, we report that intermediate-term memory (ITM), but not short-term memory (STM), in Drosophila aversive olfactory memory requires transient IIS during adulthood. The expression of Drosophila insulin-like peptide 3 (Dilp3) in insulin-producing cells and insulin receptor function in the fat body are essential for ITM. Although the expression of dilp3 decreases with aging, which is unique among dilp genes, the transient expression of dilp3 in aged flies enhances ITM. These findings indicate that ITM is systemically regulated by communication between insulin-producing cells and fat body and that age-dependent changes in IIS contribute to age-related memory impairment. |
topic |
insulin signaling learning and memory aging fat body Drosophila |
url |
http://www.sciencedirect.com/science/article/pii/S2211124717301109 |
work_keys_str_mv |
AT kentotanabe agerelatedchangesininsulinlikesignalingleadtointermediatetermmemoryimpairmentindrosophila AT motoyukiitoh agerelatedchangesininsulinlikesignalingleadtointermediatetermmemoryimpairmentindrosophila AT ayakotonoki agerelatedchangesininsulinlikesignalingleadtointermediatetermmemoryimpairmentindrosophila |
_version_ |
1725008460155715584 |