Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila

Insulin and insulin-growth-factor-like signaling (IIS) plays important roles in the regulation of development, growth, metabolic homeostasis, and aging, as well as in brain functions such as learning and memory. The temporal-spatial role of IIS in learning and memory and its effect on age-dependent...

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Main Authors: Kento Tanabe, Motoyuki Itoh, Ayako Tonoki
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Cell Reports
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717301109
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spelling doaj-ef455cf0b69f4e7c9844541ab78a0d462020-11-25T01:49:09ZengElsevierCell Reports2211-12472017-02-011871598160510.1016/j.celrep.2017.01.053Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in DrosophilaKento Tanabe0Motoyuki Itoh1Ayako Tonoki2Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, JapanGraduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, JapanGraduate School of Pharmaceutical Sciences, Chiba University, Chiba 260-8675, JapanInsulin and insulin-growth-factor-like signaling (IIS) plays important roles in the regulation of development, growth, metabolic homeostasis, and aging, as well as in brain functions such as learning and memory. The temporal-spatial role of IIS in learning and memory and its effect on age-dependent memory impairment remain unclear. Here, we report that intermediate-term memory (ITM), but not short-term memory (STM), in Drosophila aversive olfactory memory requires transient IIS during adulthood. The expression of Drosophila insulin-like peptide 3 (Dilp3) in insulin-producing cells and insulin receptor function in the fat body are essential for ITM. Although the expression of dilp3 decreases with aging, which is unique among dilp genes, the transient expression of dilp3 in aged flies enhances ITM. These findings indicate that ITM is systemically regulated by communication between insulin-producing cells and fat body and that age-dependent changes in IIS contribute to age-related memory impairment.http://www.sciencedirect.com/science/article/pii/S2211124717301109insulin signalinglearning and memoryagingfat bodyDrosophila
collection DOAJ
language English
format Article
sources DOAJ
author Kento Tanabe
Motoyuki Itoh
Ayako Tonoki
spellingShingle Kento Tanabe
Motoyuki Itoh
Ayako Tonoki
Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila
Cell Reports
insulin signaling
learning and memory
aging
fat body
Drosophila
author_facet Kento Tanabe
Motoyuki Itoh
Ayako Tonoki
author_sort Kento Tanabe
title Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila
title_short Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila
title_full Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila
title_fullStr Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila
title_full_unstemmed Age-Related Changes in Insulin-like Signaling Lead to Intermediate-Term Memory Impairment in Drosophila
title_sort age-related changes in insulin-like signaling lead to intermediate-term memory impairment in drosophila
publisher Elsevier
series Cell Reports
issn 2211-1247
publishDate 2017-02-01
description Insulin and insulin-growth-factor-like signaling (IIS) plays important roles in the regulation of development, growth, metabolic homeostasis, and aging, as well as in brain functions such as learning and memory. The temporal-spatial role of IIS in learning and memory and its effect on age-dependent memory impairment remain unclear. Here, we report that intermediate-term memory (ITM), but not short-term memory (STM), in Drosophila aversive olfactory memory requires transient IIS during adulthood. The expression of Drosophila insulin-like peptide 3 (Dilp3) in insulin-producing cells and insulin receptor function in the fat body are essential for ITM. Although the expression of dilp3 decreases with aging, which is unique among dilp genes, the transient expression of dilp3 in aged flies enhances ITM. These findings indicate that ITM is systemically regulated by communication between insulin-producing cells and fat body and that age-dependent changes in IIS contribute to age-related memory impairment.
topic insulin signaling
learning and memory
aging
fat body
Drosophila
url http://www.sciencedirect.com/science/article/pii/S2211124717301109
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AT ayakotonoki agerelatedchangesininsulinlikesignalingleadtointermediatetermmemoryimpairmentindrosophila
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