DESIGN AND SYNTHESIS OF NEW HOMO- AND HETEROMETAL COORDINATION COMPOUNDS OF GERMANIUM(IV) FOR PREPARATION OF LOW TOXIC DRUGS WITH A WIDE THERAPEUTIC ACTION

Coordination compounds of essential microelement germanium(IV) with metals (Mg, Na, K, Ca, Cu, etc.) and organic ligands – biocatalysts, antidotes at intoxications and regulators of mineral metabolism in living organism (nicotinic, citric, tartaric, 1-hydroxyethylidendiphosphonic acids, nicotinamide...

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Main Authors:	I. I. Seifullina, E. E. Martsinko, E. V. Afanasenko
Format:	Article
Language:	English
Published:	Odessa I. I. Mechnikov National University 2015-12-01
Series:	Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ
Subjects:	германій, координаційні сполуки, біоліганди, біологічна активність, терапевтична дія
Online Access:	http://heraldchem.onu.edu.ua/article/view/56690

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record_format	Article
spelling	doaj-ef41fe59405242b1b3669c6e5ebd45142020-11-25T00:12:07ZengOdessa I. I. Mechnikov National University Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ2304-09472414-59632015-12-01204(56)61710.18524/2304-0947.2015.4(56).5669056690DESIGN AND SYNTHESIS OF NEW HOMO- AND HETEROMETAL COORDINATION COMPOUNDS OF GERMANIUM(IV) FOR PREPARATION OF LOW TOXIC DRUGS WITH A WIDE THERAPEUTIC ACTIONI. I. Seifullina0E. E. MartsinkoE. V. AfanasenkoОдеський національний університет імені І. І. МечниковаCoordination compounds of essential microelement germanium(IV) with metals (Mg, Na, K, Ca, Cu, etc.) and organic ligands – biocatalysts, antidotes at intoxications and regulators of mineral metabolism in living organism (nicotinic, citric, tartaric, 1-hydroxyethylidendiphosphonic acids, nicotinamide) are synthesized for the first time on the Department of General Chemistry and Polymers of Odessa Mechnikov National University. The favorable activity of the synthesized compounds on cardiovascular and chronic respiratory diseases, senile pneumonia, neuropsychiatric and metabolic disorders, ischemic heart diseases, etc. is described. Thus, the influence of 1-hydroxyethylidendiphosphonatogermanate (medgerm) on CNS, its anxiolytic activity and absence of both hypnotic and myorelaxant effects has been shown. Cardioprotector properties of magnesium hydroxyethylidendiphosphonategermanate as a potential effective and safe drug with the high antihypertensive and antiarrhythmic activity have been found out. The interferoninductive and immunostimulatory activity of germanium(IV) compounds with 1-hydroxyethylidendiphosphonic, nicotinic acids, nicotinamide, pyracetam has been studied. Injection of these drugs (concentration 100-125 μg/ml) causes the 100 % delay of cytopathic action of vesicular stomatitis virus in the cell cultures that demonstrates the ability of compounds to increase essentially cells stability. The perspectives of germanium coordination compounds as interferon inductors and as immune pharmaceuticals for prevention the disbalance of the immune system are reviewed.http://heraldchem.onu.edu.ua/article/view/56690германій, координаційні сполуки, біоліганди, біологічна активність, терапевтична дія
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	I. I. Seifullina E. E. Martsinko E. V. Afanasenko
spellingShingle	I. I. Seifullina E. E. Martsinko E. V. Afanasenko DESIGN AND SYNTHESIS OF NEW HOMO- AND HETEROMETAL COORDINATION COMPOUNDS OF GERMANIUM(IV) FOR PREPARATION OF LOW TOXIC DRUGS WITH A WIDE THERAPEUTIC ACTION Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ германій, координаційні сполуки, біоліганди, біологічна активність, терапевтична дія
author_facet	I. I. Seifullina E. E. Martsinko E. V. Afanasenko
author_sort	I. I. Seifullina
title	DESIGN AND SYNTHESIS OF NEW HOMO- AND HETEROMETAL COORDINATION COMPOUNDS OF GERMANIUM(IV) FOR PREPARATION OF LOW TOXIC DRUGS WITH A WIDE THERAPEUTIC ACTION
title_short	DESIGN AND SYNTHESIS OF NEW HOMO- AND HETEROMETAL COORDINATION COMPOUNDS OF GERMANIUM(IV) FOR PREPARATION OF LOW TOXIC DRUGS WITH A WIDE THERAPEUTIC ACTION
title_full	DESIGN AND SYNTHESIS OF NEW HOMO- AND HETEROMETAL COORDINATION COMPOUNDS OF GERMANIUM(IV) FOR PREPARATION OF LOW TOXIC DRUGS WITH A WIDE THERAPEUTIC ACTION
title_fullStr	DESIGN AND SYNTHESIS OF NEW HOMO- AND HETEROMETAL COORDINATION COMPOUNDS OF GERMANIUM(IV) FOR PREPARATION OF LOW TOXIC DRUGS WITH A WIDE THERAPEUTIC ACTION
title_full_unstemmed	DESIGN AND SYNTHESIS OF NEW HOMO- AND HETEROMETAL COORDINATION COMPOUNDS OF GERMANIUM(IV) FOR PREPARATION OF LOW TOXIC DRUGS WITH A WIDE THERAPEUTIC ACTION
title_sort	design and synthesis of new homo- and heterometal coordination compounds of germanium(iv) for preparation of low toxic drugs with a wide therapeutic action
publisher	Odessa I. I. Mechnikov National University
series	Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ
issn	2304-0947 2414-5963
publishDate	2015-12-01
description	Coordination compounds of essential microelement germanium(IV) with metals (Mg, Na, K, Ca, Cu, etc.) and organic ligands – biocatalysts, antidotes at intoxications and regulators of mineral metabolism in living organism (nicotinic, citric, tartaric, 1-hydroxyethylidendiphosphonic acids, nicotinamide) are synthesized for the first time on the Department of General Chemistry and Polymers of Odessa Mechnikov National University. The favorable activity of the synthesized compounds on cardiovascular and chronic respiratory diseases, senile pneumonia, neuropsychiatric and metabolic disorders, ischemic heart diseases, etc. is described. Thus, the influence of 1-hydroxyethylidendiphosphonatogermanate (medgerm) on CNS, its anxiolytic activity and absence of both hypnotic and myorelaxant effects has been shown. Cardioprotector properties of magnesium hydroxyethylidendiphosphonategermanate as a potential effective and safe drug with the high antihypertensive and antiarrhythmic activity have been found out. The interferoninductive and immunostimulatory activity of germanium(IV) compounds with 1-hydroxyethylidendiphosphonic, nicotinic acids, nicotinamide, pyracetam has been studied. Injection of these drugs (concentration 100-125 μg/ml) causes the 100 % delay of cytopathic action of vesicular stomatitis virus in the cell cultures that demonstrates the ability of compounds to increase essentially cells stability. The perspectives of germanium coordination compounds as interferon inductors and as immune pharmaceuticals for prevention the disbalance of the immune system are reviewed.
topic	германій, координаційні сполуки, біоліганди, біологічна активність, терапевтична дія
url	http://heraldchem.onu.edu.ua/article/view/56690
work_keys_str_mv	AT iiseifullina designandsynthesisofnewhomoandheterometalcoordinationcompoundsofgermaniumivforpreparationoflowtoxicdrugswithawidetherapeuticaction AT eemartsinko designandsynthesisofnewhomoandheterometalcoordinationcompoundsofgermaniumivforpreparationoflowtoxicdrugswithawidetherapeuticaction AT evafanasenko designandsynthesisofnewhomoandheterometalcoordinationcompoundsofgermaniumivforpreparationoflowtoxicdrugswithawidetherapeuticaction
_version_	1725401149254664192

DESIGN AND SYNTHESIS OF NEW HOMO- AND HETEROMETAL COORDINATION COMPOUNDS OF GERMANIUM(IV) FOR PREPARATION OF LOW TOXIC DRUGS WITH A WIDE THERAPEUTIC ACTION

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