A Model for Apoptotic-Cell-Mediated Adaptive Immune Evasion via CD80–CTLA-4 Signaling

Apoptotic cells carry a plethora of self-antigens but they suppress eliciting of innate and adaptive immune responses to them. How apoptotic cells evade and subvert adaptive immune responses has been elusive. Here, we propose a novel model to understand how apoptotic cells regulate T cell activation...

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Main Authors:	Abraam M. Yakoub, Stefan Schülke
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2019-05-01
Series:	Frontiers in Pharmacology
Subjects:	apoptosis immunotolerance autoimmunity costimulatory pathway CD80 CTLA-4
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2019.00562/full

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spelling	doaj-ef3cb18d9ea24d488fd33c48868c77012020-11-25T02:03:37ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122019-05-011010.3389/fphar.2019.00562421599A Model for Apoptotic-Cell-Mediated Adaptive Immune Evasion via CD80–CTLA-4 SignalingAbraam M. Yakoub0Stefan Schülke1Department of Molecular and Cellular Physiology, School of Medicine, Stanford University, Stanford, CA, United StatesVice President’s Research Group: Molecular Allergology, Paul-Ehrlich-Institut, Langen, GermanyApoptotic cells carry a plethora of self-antigens but they suppress eliciting of innate and adaptive immune responses to them. How apoptotic cells evade and subvert adaptive immune responses has been elusive. Here, we propose a novel model to understand how apoptotic cells regulate T cell activation in different contexts, leading mostly to tolerogenic responses, mainly via taking control of the CD80–CTLA-4 coinhibitory signal delivered to T cells. This model may facilitate understanding of the molecular mechanisms of autoimmune diseases associated with dysregulation of apoptosis or apoptotic cell clearance, and it highlights potential therapeutic targets or strategies for treatment of multiple immunological disorders.https://www.frontiersin.org/article/10.3389/fphar.2019.00562/fullapoptosisimmunotoleranceautoimmunitycostimulatory pathwayCD80CTLA-4
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Abraam M. Yakoub Stefan Schülke
spellingShingle	Abraam M. Yakoub Stefan Schülke A Model for Apoptotic-Cell-Mediated Adaptive Immune Evasion via CD80–CTLA-4 Signaling Frontiers in Pharmacology apoptosis immunotolerance autoimmunity costimulatory pathway CD80 CTLA-4
author_facet	Abraam M. Yakoub Stefan Schülke
author_sort	Abraam M. Yakoub
title	A Model for Apoptotic-Cell-Mediated Adaptive Immune Evasion via CD80–CTLA-4 Signaling
title_short	A Model for Apoptotic-Cell-Mediated Adaptive Immune Evasion via CD80–CTLA-4 Signaling
title_full	A Model for Apoptotic-Cell-Mediated Adaptive Immune Evasion via CD80–CTLA-4 Signaling
title_fullStr	A Model for Apoptotic-Cell-Mediated Adaptive Immune Evasion via CD80–CTLA-4 Signaling
title_full_unstemmed	A Model for Apoptotic-Cell-Mediated Adaptive Immune Evasion via CD80–CTLA-4 Signaling
title_sort	model for apoptotic-cell-mediated adaptive immune evasion via cd80–ctla-4 signaling
publisher	Frontiers Media S.A.
series	Frontiers in Pharmacology
issn	1663-9812
publishDate	2019-05-01
description	Apoptotic cells carry a plethora of self-antigens but they suppress eliciting of innate and adaptive immune responses to them. How apoptotic cells evade and subvert adaptive immune responses has been elusive. Here, we propose a novel model to understand how apoptotic cells regulate T cell activation in different contexts, leading mostly to tolerogenic responses, mainly via taking control of the CD80–CTLA-4 coinhibitory signal delivered to T cells. This model may facilitate understanding of the molecular mechanisms of autoimmune diseases associated with dysregulation of apoptosis or apoptotic cell clearance, and it highlights potential therapeutic targets or strategies for treatment of multiple immunological disorders.
topic	apoptosis immunotolerance autoimmunity costimulatory pathway CD80 CTLA-4
url	https://www.frontiersin.org/article/10.3389/fphar.2019.00562/full
work_keys_str_mv	AT abraammyakoub amodelforapoptoticcellmediatedadaptiveimmuneevasionviacd80ctla4signaling AT stefanschulke amodelforapoptoticcellmediatedadaptiveimmuneevasionviacd80ctla4signaling AT abraammyakoub modelforapoptoticcellmediatedadaptiveimmuneevasionviacd80ctla4signaling AT stefanschulke modelforapoptoticcellmediatedadaptiveimmuneevasionviacd80ctla4signaling
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A Model for Apoptotic-Cell-Mediated Adaptive Immune Evasion via CD80–CTLA-4 Signaling

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