<b>Synthesis, stereochemistry and antimicrobial activity of copper(II) and nickel(II) complexes of 4-phenylsemicarbazones</b>

• Main Authors: Ededet A. Eno, Grace E. Iniama, Godfred A. Ayimele, Seraphine N. Esemu, Emmanuel N. Nfor, Offiong E. Offiong
• Format: Article
• Language: English
• Published: Chemical Society of Ethiopia 2011-12-01
• Series: Bulletin of the Chemical Society of Ethiopia
• Subjects: 4-Phenylsemicarbazone; Metal complexes; Stereochemistry; Antimicrobial activity
• Online Access: http://ajol.info/index.php/bcse/article/view/68588
• ISSN: 1011-3924; 1726-801X

2-Acetylpyridine-(4-phenylsemicarbazone) and <i>o</i>-vanillin-(4-phenylsemicarbazone) have been prepared and characterized on the basis of elemental analyses, infrared, electronic, ¹H and ¹³C NMR spectra. Several nickel(II) and copper(II) complexes have been obtained from these ligands. The IR spectra of the ligands as well as those of their complexes suggest that 2-acetylpyridine-(4-phenylsemicarbazone) is a neutral tridentate molecule while <i>o</i>-vanillin-(4-phenylsemicarbazone) is a monobasic tridentate molecule. On the basis of the analytical data, magnetic moments and spectral data, a square-planar geometry has been proposed for the nickel(II) and copper(II) complexes with these ligands. Some representative complexes of copper(II) and nickel(II) were found to have remarkable antifungal and antibacterial activity.