Longitudinal stability of molecular alterations and drug response profiles in tumor spheroid cell lines enables reproducible analyses

Longitudinal stability of molecular alterations and drug response profiles in tumor spheroid cell lines enables reproducible analyses

The utility of patient-derived tumor cell lines as experimental models for glioblastoma has been challenged by limited representation of the in vivo tumor biology and low clinical translatability. Here, we report on longitudinal epigenetic and transcriptional profiling of seven glioblastoma spheroid...

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Bibliographic Details
Main Authors: A.C. Nickel, D. Picard, N. Qin, M. Wolter, K. Kaulich, M. Hewera, D. Pauck, V. Marquardt, G. Torga, S. Muhammad, W. Zhang, O. Schnell, H.-J. Steiger, D. Hänggi, E. Fritsche, N.-G. Her, D.-H. Nam, M.S. Carro, M. Remke, G. Reifenberger, U.D. Kahlert
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Glioblastoma
In vitro drug screening
Longitudinal molecular profiling
Tumor spheroids
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221010623

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