The epigenome as a putative target for skin repair: the HDAC inhibitor Trichostatin A modulates myeloid progenitor plasticity and behavior and improves wound healing

The epigenome as a putative target for skin repair: the HDAC inhibitor Trichostatin A modulates myeloid progenitor plasticity and behavior and improves wound healing

Abstract Background The molecular pathways that drive bone marrow myeloid progenitors (BMMP) development are very well understood and include a tight controlled multi-stage gene hierarch. Monocytes are versatile cells that display remarkable plasticity and may give rise to specific subsets of macrop...

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Bibliographic Details
Main Authors: Mariana Cabanel, Thayse Pinheiro da Costa, Marcia Cury EL-Cheikh, Katia Carneiro
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Translational Medicine
Subjects:
Histone deacetylase
Bone marrow myeloid progenitors
Macrophage plasticity
Wound healing
Online Access:http://link.springer.com/article/10.1186/s12967-019-1998-9

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