The complexity of titin splicing pattern in human adult skeletal muscles

The complexity of titin splicing pattern in human adult skeletal muscles

Abstract Background Mutations in the titin gene (TTN) cause a large spectrum of diseases affecting skeletal and/or cardiac muscle. TTN includes 363 coding exons, a repeated region with a high degree of complexity, isoform-specific elements, and metatranscript-only exons thought to be expressed only...

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Bibliographic Details
Main Authors: Marco Savarese, Per Harald Jonson, Sanna Huovinen, Lars Paulin, Petri Auvinen, Bjarne Udd, Peter Hackman
Format: Article
Language:English
Published: BMC 2018-03-01
Series:Skeletal Muscle
Subjects:
Titin
Titinopathies
RNA-sequencing
Exon usage
Alternative splicing events
Splicing pattern
Online Access:http://link.springer.com/article/10.1186/s13395-018-0156-z

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