Abnormal Development of the Earliest Cortical Circuits in a Mouse Model of Autism Spectrum Disorder

Abnormal Development of the Earliest Cortical Circuits in a Mouse Model of Autism Spectrum Disorder

Autism spectrum disorder (ASD) involves deficits in speech and sound processing. Cortical circuit changes during early development likely contribute to such deficits. Subplate neurons (SPNs) form the earliest cortical microcircuits and are required for normal development of thalamocortical and intra...

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Bibliographic Details
Main Authors: Daniel A. Nagode, Xiangying Meng, Daniel E. Winkowski, Ed Smith, Hamza Khan-Tareen, Vishnupriya Kareddy, Joseph P.Y. Kao, Patrick O. Kanold
Format: Article
Language:English
Published: Elsevier 2017-01-01
Series:Cell Reports
Subjects:
subplate
autism
cortex
development
valproate
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717300244

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