Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro

Low Molecular Weight Hyaluronan Induces an Inflammatory Response in Ovarian Stromal Cells and Impairs Gamete Development In Vitro

The ovarian stroma, the microenvironment in which female gametes grow and mature, becomes inflamed and fibrotic with age. Hyaluronan is a major component of the ovarian extracellular matrix (ECM), and in other aging tissues, accumulation of low molecular weight (LMW) hyaluronan fragments can drive i...

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Bibliographic Details
Main Authors: Jennifer E. Rowley, Farners Amargant, Luhan T. Zhou, Anna Galligos, Leah E. Simon, Michele T. Pritchard, Francesca E. Duncan
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:International Journal of Molecular Sciences
Subjects:
hyaluronan fragments
stroma
inflammation
ovarian biology
reproductive aging
Online Access:https://www.mdpi.com/1422-0067/21/3/1036

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