Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host Interaction
The interaction between gut microbiota and host plays a central role in health. Dysbiosis, detrimental changes in gut microbiota and inflammation have been reported in non-communicable diseases. While diet has a profound impact on gut microbiota composition and function, the role of food additives s...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-05-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnut.2019.00057/full |
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DOAJ |
| language |
English |
| format |
Article |
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DOAJ |
| author |
Gabriela Pinget Gabriela Pinget Gabriela Pinget Jian Tan Jian Tan Jian Tan Jian Tan Bartlomiej Janac Bartlomiej Janac Nadeem O. Kaakoush Alexandra Sophie Angelatos Alexandra Sophie Angelatos John O'Sullivan Yen Chin Koay Frederic Sierro Joel Davis Shiva Kamini Divakarla Shiva Kamini Divakarla Dipesh Khanal Dipesh Khanal Robert J. Moore Dragana Stanley Wojciech Chrzanowski Wojciech Chrzanowski Laurence Macia Laurence Macia Laurence Macia |
| spellingShingle |
Gabriela Pinget Gabriela Pinget Gabriela Pinget Jian Tan Jian Tan Jian Tan Jian Tan Bartlomiej Janac Bartlomiej Janac Nadeem O. Kaakoush Alexandra Sophie Angelatos Alexandra Sophie Angelatos John O'Sullivan Yen Chin Koay Frederic Sierro Joel Davis Shiva Kamini Divakarla Shiva Kamini Divakarla Dipesh Khanal Dipesh Khanal Robert J. Moore Dragana Stanley Wojciech Chrzanowski Wojciech Chrzanowski Laurence Macia Laurence Macia Laurence Macia Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host Interaction Frontiers in Nutrition biofilm gut microbiota immune cells inflammation titanium dioxide |
| author_facet |
Gabriela Pinget Gabriela Pinget Gabriela Pinget Jian Tan Jian Tan Jian Tan Jian Tan Bartlomiej Janac Bartlomiej Janac Nadeem O. Kaakoush Alexandra Sophie Angelatos Alexandra Sophie Angelatos John O'Sullivan Yen Chin Koay Frederic Sierro Joel Davis Shiva Kamini Divakarla Shiva Kamini Divakarla Dipesh Khanal Dipesh Khanal Robert J. Moore Dragana Stanley Wojciech Chrzanowski Wojciech Chrzanowski Laurence Macia Laurence Macia Laurence Macia |
| author_sort |
Gabriela Pinget |
| title |
Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host Interaction |
| title_short |
Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host Interaction |
| title_full |
Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host Interaction |
| title_fullStr |
Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host Interaction |
| title_full_unstemmed |
Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host Interaction |
| title_sort |
impact of the food additive titanium dioxide (e171) on gut microbiota-host interaction |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Nutrition |
| issn |
2296-861X |
| publishDate |
2019-05-01 |
| description |
The interaction between gut microbiota and host plays a central role in health. Dysbiosis, detrimental changes in gut microbiota and inflammation have been reported in non-communicable diseases. While diet has a profound impact on gut microbiota composition and function, the role of food additives such as titanium dioxide (TiO2), prevalent in processed food, is less established. In this project, we investigated the impact of food grade TiO2 on gut microbiota of mice when orally administered via drinking water. While TiO2 had minimal impact on the composition of the microbiota in the small intestine and colon, we found that TiO2 treatment could alter the release of bacterial metabolites in vivo and affect the spatial distribution of commensal bacteria in vitro by promoting biofilm formation. We also found reduced expression of the colonic mucin 2 gene, a key component of the intestinal mucus layer, and increased expression of the beta defensin gene, indicating that TiO2 significantly impacts gut homeostasis. These changes were associated with colonic inflammation, as shown by decreased crypt length, infiltration of CD8+ T cells, increased macrophages as well as increased expression of inflammatory cytokines. These findings collectively show that TiO2 is not inert, but rather impairs gut homeostasis which may in turn prime the host for disease development. |
| topic |
biofilm gut microbiota immune cells inflammation titanium dioxide |
| url |
https://www.frontiersin.org/article/10.3389/fnut.2019.00057/full |
| work_keys_str_mv |
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doaj-ef17681ab7cc408e834566243a3b57b22020-11-25T01:49:37ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2019-05-01610.3389/fnut.2019.00057446992Impact of the Food Additive Titanium Dioxide (E171) on Gut Microbiota-Host InteractionGabriela Pinget0Gabriela Pinget1Gabriela Pinget2Jian Tan3Jian Tan4Jian Tan5Jian Tan6Bartlomiej Janac7Bartlomiej Janac8Nadeem O. Kaakoush9Alexandra Sophie Angelatos10Alexandra Sophie Angelatos11John O'Sullivan12Yen Chin Koay13Frederic Sierro14Joel Davis15Shiva Kamini Divakarla16Shiva Kamini Divakarla17Dipesh Khanal18Dipesh Khanal19Robert J. Moore20Dragana Stanley21Wojciech Chrzanowski22Wojciech Chrzanowski23Laurence Macia24Laurence Macia25Laurence Macia26The Charles Perkins Centre, The University of Sydney, Sydney, NSW, AustraliaFaculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, AustraliaSydney Nano Institute, The University of Sydney, Sydney, NSW, AustraliaThe Charles Perkins Centre, The University of Sydney, Sydney, NSW, AustraliaFaculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, AustraliaSydney Nano Institute, The University of Sydney, Sydney, NSW, AustraliaHuman Health, Nuclear Science & Technology and Landmark Infrastructure (NSTLI), Australian Nuclear Science and Technology Organisation, Sydney, NSW, AustraliaThe Charles Perkins Centre, The University of Sydney, Sydney, NSW, AustraliaFaculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, AustraliaSchool of Medical Sciences, University of New South Wales, Sydney, NSW, AustraliaThe Charles Perkins Centre, The University of Sydney, Sydney, NSW, AustraliaFaculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, AustraliaDepartment of Cardiology, Charles Perkins Centre, Royal Prince Alfred Hospital, Heart Research Institute, University of Sydney, Sydney, NSW, AustraliaDepartment of Cardiology, Charles Perkins Centre, Royal Prince Alfred Hospital, Heart Research Institute, University of Sydney, Sydney, NSW, AustraliaHuman Health, Nuclear Science & Technology and Landmark Infrastructure (NSTLI), Australian Nuclear Science and Technology Organisation, Sydney, NSW, AustraliaHuman Health, Nuclear Science & Technology and Landmark Infrastructure (NSTLI), Australian Nuclear Science and Technology Organisation, Sydney, NSW, AustraliaSydney Nano Institute, The University of Sydney, Sydney, NSW, AustraliaSydney Pharmacy School, The University of Sydney, Sydney, NSW, AustraliaSydney Nano Institute, The University of Sydney, Sydney, NSW, AustraliaSydney Pharmacy School, The University of Sydney, Sydney, NSW, AustraliaSchool of Science, RMIT University, Bundoora, VIC, AustraliaSchool of Health, Medical and Applied Sciences, Central Queensland University, Rockhampton, QLD, AustraliaSydney Nano Institute, The University of Sydney, Sydney, NSW, AustraliaSydney Pharmacy School, The University of Sydney, Sydney, NSW, AustraliaThe Charles Perkins Centre, The University of Sydney, Sydney, NSW, AustraliaFaculty of Medicine and Health, School of Medical Sciences, The University of Sydney, Sydney, NSW, AustraliaSydney Nano Institute, The University of Sydney, Sydney, NSW, AustraliaThe interaction between gut microbiota and host plays a central role in health. Dysbiosis, detrimental changes in gut microbiota and inflammation have been reported in non-communicable diseases. While diet has a profound impact on gut microbiota composition and function, the role of food additives such as titanium dioxide (TiO2), prevalent in processed food, is less established. In this project, we investigated the impact of food grade TiO2 on gut microbiota of mice when orally administered via drinking water. While TiO2 had minimal impact on the composition of the microbiota in the small intestine and colon, we found that TiO2 treatment could alter the release of bacterial metabolites in vivo and affect the spatial distribution of commensal bacteria in vitro by promoting biofilm formation. We also found reduced expression of the colonic mucin 2 gene, a key component of the intestinal mucus layer, and increased expression of the beta defensin gene, indicating that TiO2 significantly impacts gut homeostasis. These changes were associated with colonic inflammation, as shown by decreased crypt length, infiltration of CD8+ T cells, increased macrophages as well as increased expression of inflammatory cytokines. These findings collectively show that TiO2 is not inert, but rather impairs gut homeostasis which may in turn prime the host for disease development.https://www.frontiersin.org/article/10.3389/fnut.2019.00057/fullbiofilmgut microbiotaimmune cellsinflammationtitanium dioxide |