Control of middle ear inflammatory and ion homeostasis genes by transtympanic glucocorticoid and mineralocorticoid treatments.

Control of middle ear inflammatory and ion homeostasis genes by transtympanic glucocorticoid and mineralocorticoid treatments.

Transtympanic steroid treatment will induce changes in ion homeostasis and inflammatory gene expression to decrease middle ear inflammation due to bacterial inoculation.Otitis media is common, but treatment options are limited to systemic antibiotic therapy or surgical intervention. Systemic glucoco...

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Bibliographic Details
Main Authors: Jessyka G Lighthall, J Beth Kempton, Frances Hausman, Carol J MacArthur, Dennis R Trune
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4374692?pdf=render

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