Advances in pathogenic mechanisms and management of radiation-induced fibrosis

Advances in pathogenic mechanisms and management of radiation-induced fibrosis

Radiation-induced fibrosis (RIF) is a severe long-term complication of the normal tissue following radiotherapy. Its prototypical characteristic is the persistent activation of myofibroblasts, resulting in proportion disorder and hyperplasia remodeling of the extracellular matrix comprising collagen...

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Bibliographic Details
Main Authors: Bin Wang, Jinlong Wei, Lingbin Meng, Huanhuan Wang, Chao Qu, Xiang Chen, Ying Xin, Xin Jiang
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Radiotherapy
Radiation-induced fibrosis
ROS
TGF-β1
Management strategies
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219351832

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