A detailed physiologically-based model to simulate the pharmacokinetics and hormonal pharmacodynamics of enalapril on the circulating endocrine renin-angiotensin-aldosterone system

A detailed physiologically-based model to simulate the pharmacokinetics and hormonal pharmacodynamics of enalapril on the circulating endocrine renin-angiotensin-aldosterone system

The renin-angiotensin-aldosterone system (RAAS) plays a key role in the pathogenesis of cardiovascular disorders including hypertension and is one of the most important targets for drugs. A whole body physiologically-based pharmacokinetic (wb PBPK) model integrating this hormone circulation system a...

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Bibliographic Details
Main Authors:	Karina eClaassen, Stefan eWillmann, Thomas eEissing, Tobias ePreusser, Michael eBlock
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2013-02-01
Series:	Frontiers in Physiology
Subjects:	Enalapril Enalaprilat cardiovascular Physiologically-based pharmacokinetic model renin-angiotensin-aldosterone system
Online Access:	http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00004/full

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