SCH00013, a Novel Ca2+ Sensitizer With Positive Inotropic and No Chronotropic Action in Heart Failure

SCH00013, a Novel Ca2+ Sensitizer With Positive Inotropic and No Chronotropic Action in Heart Failure

We investigated the effects of the agent SCH00013 on Ca2+-induced force generation in rabbit skinned cardiac muscle fibers and in vivo cardiac function in high-pacing-induced heart failure dogs. The Ca2+-induced force generation in skinned cardiac muscle fibers was determined at pH 6.2 – 7.4, and SC...

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Main Authors: Naoto Tadano, Sachio Morimoto, Akira Yoshimura, Makoto Miura, Kimitomo Yoshioka, Mitsuo Sakato, Iwao Ohtsuki, Yoshikazu Miwa, Fumi Takahashi-Yanaga, Toshiyuki Sasaguri
Format: Article
Language:English
Published: Elsevier 2005-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319322935

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