Self-organized intestinal epithelial monolayers in crypt and villus-like domains show effective barrier function
Abstract Intestinal organoids have emerged as a powerful in vitro tool for studying intestinal biology due to their resemblance to in vivo tissue at the structural and functional levels. However, their sphere-like geometry prevents access to the apical side of the epithelium, making them unsuitable...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-07-01
|
| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-019-46497-x |