A revised Sorensen model: Simulating glycemic and insulinemic response to oral and intra-venous glucose load.

A revised Sorensen model: Simulating glycemic and insulinemic response to oral and intra-venous glucose load.

In 1978, Thomas J. Sorensen defended a thesis in chemical engineering at the University of California, Berkeley, where he proposed an extensive model of glucose-insulin control, model which was thereafter widely employed for virtual patient simulation. The original model, and even more so its subseq...

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Main Authors: Simona Panunzi, Marcello Pompa, Alessandro Borri, Vincenzo Piemonte, Andrea De Gaetano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0237215
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spelling doaj-eeedc6f886f2462ea33cf036df93e8b82021-03-03T22:00:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01158e023721510.1371/journal.pone.0237215A revised Sorensen model: Simulating glycemic and insulinemic response to oral and intra-venous glucose load.Simona PanunziMarcello PompaAlessandro BorriVincenzo PiemonteAndrea De GaetanoIn 1978, Thomas J. Sorensen defended a thesis in chemical engineering at the University of California, Berkeley, where he proposed an extensive model of glucose-insulin control, model which was thereafter widely employed for virtual patient simulation. The original model, and even more so its subsequent implementations by other Authors, presented however a few imprecisions in reporting the correct model equations and parameter values. The goal of the present work is to revise the original Sorensen's model, to clearly summarize its defining equations, to supplement it with a missing gastrio-intestinal glucose absorption and to make an implementation of the revised model available on-line to the scientific community.https://doi.org/10.1371/journal.pone.0237215
collection DOAJ
language English
format Article
sources DOAJ
author Simona Panunzi
Marcello Pompa
Alessandro Borri
Vincenzo Piemonte
Andrea De Gaetano
spellingShingle Simona Panunzi
Marcello Pompa
Alessandro Borri
Vincenzo Piemonte
Andrea De Gaetano
A revised Sorensen model: Simulating glycemic and insulinemic response to oral and intra-venous glucose load.
PLoS ONE
author_facet Simona Panunzi
Marcello Pompa
Alessandro Borri
Vincenzo Piemonte
Andrea De Gaetano
author_sort Simona Panunzi
title A revised Sorensen model: Simulating glycemic and insulinemic response to oral and intra-venous glucose load.
title_short A revised Sorensen model: Simulating glycemic and insulinemic response to oral and intra-venous glucose load.
title_full A revised Sorensen model: Simulating glycemic and insulinemic response to oral and intra-venous glucose load.
title_fullStr A revised Sorensen model: Simulating glycemic and insulinemic response to oral and intra-venous glucose load.
title_full_unstemmed A revised Sorensen model: Simulating glycemic and insulinemic response to oral and intra-venous glucose load.
title_sort revised sorensen model: simulating glycemic and insulinemic response to oral and intra-venous glucose load.
publisher Public Library of Science (PLoS)
series PLoS ONE
issn 1932-6203
publishDate 2020-01-01
description In 1978, Thomas J. Sorensen defended a thesis in chemical engineering at the University of California, Berkeley, where he proposed an extensive model of glucose-insulin control, model which was thereafter widely employed for virtual patient simulation. The original model, and even more so its subsequent implementations by other Authors, presented however a few imprecisions in reporting the correct model equations and parameter values. The goal of the present work is to revise the original Sorensen's model, to clearly summarize its defining equations, to supplement it with a missing gastrio-intestinal glucose absorption and to make an implementation of the revised model available on-line to the scientific community.
url https://doi.org/10.1371/journal.pone.0237215
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