Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis

The structure of human tumor suppressor p53 in complex with the antiapoptotic protein BCL-xL reveals the basis of the p53–BCL-xL interaction and provides insight into the mechanisms of p53-mediated mitochondrial apoptosis.

Bibliographic Details
Main Authors:	Hudie Wei, Lingzhi Qu, Shuyan Dai, Yun Li, Haolan Wang, Yilu Feng, Xiaojuan Chen, Longying Jiang, Ming Guo, Jun Li, Zhuchu Chen, Lin Chen, Ye Zhang, Yongheng Chen
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-22655-6

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spelling	doaj-eee86fb8caf449e7a93cc5a90e776ac62021-04-18T11:13:33ZengNature Publishing GroupNature Communications2041-17232021-04-011211910.1038/s41467-021-22655-6Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosisHudie Wei0Lingzhi Qu1Shuyan Dai2Yun Li3Haolan Wang4Yilu Feng5Xiaojuan Chen6Longying Jiang7Ming Guo8Jun Li9Zhuchu Chen10Lin Chen11Ye Zhang12Yongheng Chen13Department of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South UniversityMolecular and Computational Biology Program, Department of Biological Sciences and Department of Chemistry, University of Southern CaliforniaDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South UniversityDepartment of Oncology, NHC Key Laboratory of Cancer Proteomics, Laboratory of Structural Biology, Xiangya Hospital, Central South UniversityThe structure of human tumor suppressor p53 in complex with the antiapoptotic protein BCL-xL reveals the basis of the p53–BCL-xL interaction and provides insight into the mechanisms of p53-mediated mitochondrial apoptosis.https://doi.org/10.1038/s41467-021-22655-6
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Hudie Wei Lingzhi Qu Shuyan Dai Yun Li Haolan Wang Yilu Feng Xiaojuan Chen Longying Jiang Ming Guo Jun Li Zhuchu Chen Lin Chen Ye Zhang Yongheng Chen
spellingShingle	Hudie Wei Lingzhi Qu Shuyan Dai Yun Li Haolan Wang Yilu Feng Xiaojuan Chen Longying Jiang Ming Guo Jun Li Zhuchu Chen Lin Chen Ye Zhang Yongheng Chen Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis Nature Communications
author_facet	Hudie Wei Lingzhi Qu Shuyan Dai Yun Li Haolan Wang Yilu Feng Xiaojuan Chen Longying Jiang Ming Guo Jun Li Zhuchu Chen Lin Chen Ye Zhang Yongheng Chen
author_sort	Hudie Wei
title	Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
title_short	Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
title_full	Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
title_fullStr	Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
title_full_unstemmed	Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
title_sort	structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-04-01
description	The structure of human tumor suppressor p53 in complex with the antiapoptotic protein BCL-xL reveals the basis of the p53–BCL-xL interaction and provides insight into the mechanisms of p53-mediated mitochondrial apoptosis.
url	https://doi.org/10.1038/s41467-021-22655-6
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Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis

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