Physical principles of retroviral integration in the human genome

Physical principles of retroviral integration in the human genome

Some retroviruses, including HIV, insert their DNA in a non-random manner in the host genome through a poorly understood selection mechanism. Here the authors develop a biophysical model of retroviral integration, identifying previously unnoticed universal principles that regulate this phenomenon.

Bibliographic Details
Main Authors: D. Michieletto, M. Lusic, D. Marenduzzo, E. Orlandini
Format: Article
Language:English
Published: Nature Publishing Group 2019-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08333-8
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spelling doaj-eee16ed719ac44e5aff0f7d03eec50d52021-05-11T12:12:58ZengNature Publishing GroupNature Communications2041-17232019-02-0110111110.1038/s41467-019-08333-8Physical principles of retroviral integration in the human genomeD. Michieletto0M. Lusic1D. Marenduzzo2E. Orlandini3SUPA, School of Physics and Astronomy, University of EdinburghDepartment of Infectious Diseases, Integrative Virology, Heidelberg University Hospital and German Center for Infection ResearchSUPA, School of Physics and Astronomy, University of EdinburghDipartimento di Fisica e Astronomia and Sezione INFN, Universitá di PadovaSome retroviruses, including HIV, insert their DNA in a non-random manner in the host genome through a poorly understood selection mechanism. Here the authors develop a biophysical model of retroviral integration, identifying previously unnoticed universal principles that regulate this phenomenon.https://doi.org/10.1038/s41467-019-08333-8
collection DOAJ
language English
format Article
sources DOAJ
author D. Michieletto
M. Lusic
D. Marenduzzo
E. Orlandini
spellingShingle D. Michieletto
M. Lusic
D. Marenduzzo
E. Orlandini
Physical principles of retroviral integration in the human genome
Nature Communications
author_facet D. Michieletto
M. Lusic
D. Marenduzzo
E. Orlandini
author_sort D. Michieletto
title Physical principles of retroviral integration in the human genome
title_short Physical principles of retroviral integration in the human genome
title_full Physical principles of retroviral integration in the human genome
title_fullStr Physical principles of retroviral integration in the human genome
title_full_unstemmed Physical principles of retroviral integration in the human genome
title_sort physical principles of retroviral integration in the human genome
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-02-01
description Some retroviruses, including HIV, insert their DNA in a non-random manner in the host genome through a poorly understood selection mechanism. Here the authors develop a biophysical model of retroviral integration, identifying previously unnoticed universal principles that regulate this phenomenon.
url https://doi.org/10.1038/s41467-019-08333-8
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AT mlusic physicalprinciplesofretroviralintegrationinthehumangenome
AT dmarenduzzo physicalprinciplesofretroviralintegrationinthehumangenome
AT eorlandini physicalprinciplesofretroviralintegrationinthehumangenome
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