Oxidative stress inhibits the proliferation, induces premature senescence and promotes a catabolic phenotype in human nucleus pulposus intervertebral disc cells
Aged and degenerated intervertebral discs are characterised by a significant increase in the number of senescent cells, which may be associated with the deterioration of this tissue due to their catabolic phenotype. On the other hand, carboxymethyl-lysine has been found to be accumulated with ageing...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
AO Research Institute Davos
2015-09-01
|
| Series: | European Cells & Materials |
| Subjects: | |
| Online Access: | http://www.ecmjournal.org/papers/vol030/pdf/v030a07.pdf |