Ca2+-activated Cl− channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration

Ca2+-activated Cl− channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration

The Ca2+-activated Cl- channel TMEM16A/Anoctamin 1 (ANO1) mediates secretion and intestinal motility in gastrointestinal epithelia and smooth muscle cells. Here, the authors show a role for ANO1 in zebrafish skeletal muscle which is activated by SR Ca2+ release during excitation-contraction coupling...

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Main Authors: Anamika Dayal, Shu Fun J. Ng, Manfred Grabner
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07918-z
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spelling doaj-eecf8fc155dd48389921310afcc01f442021-05-11T11:58:35ZengNature Publishing GroupNature Communications2041-17232019-01-0110111510.1038/s41467-018-07918-zCa2+-activated Cl− channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential accelerationAnamika Dayal0Shu Fun J. Ng1Manfred Grabner2Department of Medical Genetics, Molecular and Clinical Pharmacology, Division of Biochemical Pharmacology, Medical University of InnsbruckDepartment of Medical Genetics, Molecular and Clinical Pharmacology, Division of Biochemical Pharmacology, Medical University of InnsbruckDepartment of Medical Genetics, Molecular and Clinical Pharmacology, Division of Biochemical Pharmacology, Medical University of InnsbruckThe Ca2+-activated Cl- channel TMEM16A/Anoctamin 1 (ANO1) mediates secretion and intestinal motility in gastrointestinal epithelia and smooth muscle cells. Here, the authors show a role for ANO1 in zebrafish skeletal muscle which is activated by SR Ca2+ release during excitation-contraction coupling.https://doi.org/10.1038/s41467-018-07918-z
collection DOAJ
language English
format Article
sources DOAJ
author Anamika Dayal
Shu Fun J. Ng
Manfred Grabner
spellingShingle Anamika Dayal
Shu Fun J. Ng
Manfred Grabner
Ca2+-activated Cl− channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration
Nature Communications
author_facet Anamika Dayal
Shu Fun J. Ng
Manfred Grabner
author_sort Anamika Dayal
title Ca2+-activated Cl− channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration
title_short Ca2+-activated Cl− channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration
title_full Ca2+-activated Cl− channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration
title_fullStr Ca2+-activated Cl− channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration
title_full_unstemmed Ca2+-activated Cl− channel TMEM16A/ANO1 identified in zebrafish skeletal muscle is crucial for action potential acceleration
title_sort ca2+-activated cl− channel tmem16a/ano1 identified in zebrafish skeletal muscle is crucial for action potential acceleration
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-01-01
description The Ca2+-activated Cl- channel TMEM16A/Anoctamin 1 (ANO1) mediates secretion and intestinal motility in gastrointestinal epithelia and smooth muscle cells. Here, the authors show a role for ANO1 in zebrafish skeletal muscle which is activated by SR Ca2+ release during excitation-contraction coupling.
url https://doi.org/10.1038/s41467-018-07918-z
work_keys_str_mv AT anamikadayal ca2activatedclchanneltmem16aano1identifiedinzebrafishskeletalmuscleiscrucialforactionpotentialacceleration
AT shufunjng ca2activatedclchanneltmem16aano1identifiedinzebrafishskeletalmuscleiscrucialforactionpotentialacceleration
AT manfredgrabner ca2activatedclchanneltmem16aano1identifiedinzebrafishskeletalmuscleiscrucialforactionpotentialacceleration
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