Continuous Drug Infusion for Diabetes Therapy: A Closed-Loop Control System Design

• Main Authors: Xiao Yang, Su Xu(Kevin), Chen Jiming, Cao Kejie, Sun Youxian
• Format: Article
• Language: English
• Published: SpringerOpen 2008-01-01
• Series: EURASIP Journal on Wireless Communications and Networking
• Online Access: http://jwcn.eurasipjournals.com/content/2008/495185

<p>Abstract</p> <p>While a typical way for diabetes therapy is discrete insulin infusion based on long-time interval measurement, in this paper, we design a closed-loop control system for continuous drug infusion to improve the traditional discrete methods and make diabetes therapy automatic in practice. By exploring the accumulative function of drug to insulin, a continuous injection model is proposed. Based on this model, proportional-integral-derivative (PID) and fuzzy logic controllers are designed to tackle a control problem of the resulting highly nonlinear plant. Even with serious disturbance of glucose, such as nutrition absorption at meal time, the proposed scheme can perform well in simulation experiments.</p>