Immunomodulation of T Helper Cells by Tumor Microenvironment in Oral Cancer Is Associated With CCR8 Expression and Rapid Membrane Vitamin D Signaling Pathway

Immunomodulation of T Helper Cells by Tumor Microenvironment in Oral Cancer Is Associated With CCR8 Expression and Rapid Membrane Vitamin D Signaling Pathway

The immune system plays a key role in the protective response against oral cancer; however, the tumor microenvironment (TME) impairs this anti-cancer response by modulating T helper (Th) responses and promoting an anti-inflammatory environment. Regulatory T cells (Tregs) and Th2 effector cells (Teff...

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Bibliographic Details
Main Authors: Marco Fraga, Milly Yáñez, Macarena Sherman, Faryd Llerena, Mauricio Hernandez, Guillermo Nourdin, Francisco Álvarez, Joaquín Urrizola, César Rivera, Liliana Lamperti, Lorena Nova, Silvia Castro, Omar Zambrano, Alejandro Cifuentes, León Campos, Sergio Moya, Juan Pastor, Marcelo Nuñez, Jorge Gatica, Jorge Figueroa, Felipe Zúñiga, Carlos Salomón, Gustavo Cerda, Ricardo Puentes, Gonzalo Labarca, Mabel Vidal, Reuben McGregor, Estefania Nova-Lamperti
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
oral cancer
immunomodulation
cancer immunology
Th-like Tregs
CCR8
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.643298/full

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