Desmoglein ELISA in the Diagnosis of Pemphigus and Its Correlation with the Severity of Pemphigus Vulgaris

• Main Authors: Mortazavi Hossein, Shahdi Majid, Amirzargar Ali Akbar, S.Naraghi Zahra, Valikhani Mahin, Daneshpazhooh Maryam, Vasheghani-Farahani Amir, Sedaghat Mojtaba, Chams-Davatchi Cheyda
• Format: Article
• Language: English
• Published: Tehran University of Medical Sciences 2009-03-01
• Series: Iranian Journal of Allergy, Asthma and Immunology
• Online Access: https://ijaai.tums.ac.ir/index.php/ijaai/article/view/234
• ISSN: 1735-1502; 1735-5249

Anti-desmoglein 3 and 1 autoantibodies are involved in the pathogenesis of pemphigus diseases. Our objective was to assess the value of ELISA in the diagnosis of pemphigus and its correlation with the severity of pemphigus vulgaris. Based on clinical presentation and histopathologic confirmation for the diagnosis of the pemphigus, 38 patients took part in the study. Sera of the patients were tested by desmoglein 1 and desmoglein 3 ELISA. Also, direct immunofluorescence was performed for all patients which revealed positive results in 36 patients (94.7%). ELISA was positive in 37 of 38 pemphigus patients (Sensitivity: 97.3%). The relationship between desmoglein 1 index values and skin severity was statistically significant (p