Intraoperative Speckle Variance Optical Coherence Tomography for Tissue Temperature Monitoring During Cutaneous Laser Therapy
Background: Tissue temperature monitoring during cutaneous laser therapy can lead to safer and more effective treatments. In this study, we investigate the use of speckle variance optical coherence tomography (svOCT) to monitor real-time temperature changes in the excised human skin tissue sample du...
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IEEE
2019-01-01
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| Series: | IEEE Journal of Translational Engineering in Health and Medicine |
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| Online Access: | https://ieeexplore.ieee.org/document/8848441/ |
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doaj-eec3b906bf724873a39322cfce8a99be2021-03-29T18:40:45ZengIEEEIEEE Journal of Translational Engineering in Health and Medicine2168-23722019-01-0171810.1109/JTEHM.2019.29433178848441Intraoperative Speckle Variance Optical Coherence Tomography for Tissue Temperature Monitoring During Cutaneous Laser TherapyShoujing Guo0https://orcid.org/0000-0002-4737-4216Shuwen Wei1Soohyun Lee2https://orcid.org/0000-0002-1541-5175Mary Sheu3Sewon Kang4Jin U. Kang5Electrical and Computer Engineering Department, Johns Hopkins University, Baltimore, MD, USAElectrical and Computer Engineering Department, Johns Hopkins University, Baltimore, MD, USAElectrical and Computer Engineering Department, Johns Hopkins University, Baltimore, MD, USADepartment of Dermatology, Johns Hopkins Medicine - Green Spring Station, Lutherville, MD, USADepartment of Dermatology, The Johns Hopkins Hospital, Baltimore, MD, USAElectrical and Computer Engineering Department, Johns Hopkins University, Baltimore, MD, USABackground: Tissue temperature monitoring during cutaneous laser therapy can lead to safer and more effective treatments. In this study, we investigate the use of speckle variance optical coherence tomography (svOCT) to monitor real-time temperature changes in the excised human skin tissue sample during laser irradiation. Methods: To accomplish this, we combined the pulse laser system with a reference-based svOCT system. To calibrate the svOCT, the ex-vivo human skin samples from three individuals with tissues collected from the arm, face, and back were heated with 1-degree increments. Additionally, linear regression was used to extract and evaluate the linear relationship between the temperature and normalized speckle variance value. Experiments were conducted on excised human skin sample to monitor the temperature change during laser therapy with a svOCT system. Thermal modeling of ex-vivo human skin was used to numerically simulate the laser-tissue interaction and estimate the thermal diffusion and peak temperature of the tissue during the laser treatment. Results and Conclusion: These results showed that normalized speckle variance had a linear relationship with the tissue temperature before the onset of tissue coagulation (52°) and we were able to measure the rapid increase of the tissue temperature during laser therapy. The result of the experiment is also in good agreement with the numerical simulation result that estimated the laser-induced peak temperature and thermal relaxation time.https://ieeexplore.ieee.org/document/8848441/Cutaneous laser therapyspeckle variance OCTtissue temperature monitoringthermal modeling of tissue |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Shoujing Guo Shuwen Wei Soohyun Lee Mary Sheu Sewon Kang Jin U. Kang |
| spellingShingle |
Shoujing Guo Shuwen Wei Soohyun Lee Mary Sheu Sewon Kang Jin U. Kang Intraoperative Speckle Variance Optical Coherence Tomography for Tissue Temperature Monitoring During Cutaneous Laser Therapy IEEE Journal of Translational Engineering in Health and Medicine Cutaneous laser therapy speckle variance OCT tissue temperature monitoring thermal modeling of tissue |
| author_facet |
Shoujing Guo Shuwen Wei Soohyun Lee Mary Sheu Sewon Kang Jin U. Kang |
| author_sort |
Shoujing Guo |
| title |
Intraoperative Speckle Variance Optical Coherence Tomography for Tissue Temperature Monitoring During Cutaneous Laser Therapy |
| title_short |
Intraoperative Speckle Variance Optical Coherence Tomography for Tissue Temperature Monitoring During Cutaneous Laser Therapy |
| title_full |
Intraoperative Speckle Variance Optical Coherence Tomography for Tissue Temperature Monitoring During Cutaneous Laser Therapy |
| title_fullStr |
Intraoperative Speckle Variance Optical Coherence Tomography for Tissue Temperature Monitoring During Cutaneous Laser Therapy |
| title_full_unstemmed |
Intraoperative Speckle Variance Optical Coherence Tomography for Tissue Temperature Monitoring During Cutaneous Laser Therapy |
| title_sort |
intraoperative speckle variance optical coherence tomography for tissue temperature monitoring during cutaneous laser therapy |
| publisher |
IEEE |
| series |
IEEE Journal of Translational Engineering in Health and Medicine |
| issn |
2168-2372 |
| publishDate |
2019-01-01 |
| description |
Background: Tissue temperature monitoring during cutaneous laser therapy can lead to safer and more effective treatments. In this study, we investigate the use of speckle variance optical coherence tomography (svOCT) to monitor real-time temperature changes in the excised human skin tissue sample during laser irradiation. Methods: To accomplish this, we combined the pulse laser system with a reference-based svOCT system. To calibrate the svOCT, the ex-vivo human skin samples from three individuals with tissues collected from the arm, face, and back were heated with 1-degree increments. Additionally, linear regression was used to extract and evaluate the linear relationship between the temperature and normalized speckle variance value. Experiments were conducted on excised human skin sample to monitor the temperature change during laser therapy with a svOCT system. Thermal modeling of ex-vivo human skin was used to numerically simulate the laser-tissue interaction and estimate the thermal diffusion and peak temperature of the tissue during the laser treatment. Results and Conclusion: These results showed that normalized speckle variance had a linear relationship with the tissue temperature before the onset of tissue coagulation (52°) and we were able to measure the rapid increase of the tissue temperature during laser therapy. The result of the experiment is also in good agreement with the numerical simulation result that estimated the laser-induced peak temperature and thermal relaxation time. |
| topic |
Cutaneous laser therapy speckle variance OCT tissue temperature monitoring thermal modeling of tissue |
| url |
https://ieeexplore.ieee.org/document/8848441/ |
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